Tissue inhibitors of metalloproteinases (TIMPs) are the major cellular inhibitors of the matrix
metalloproteinase (MMP) sub-family, exhibiting varying efficacy against different members …

Abstract Objective: Matrix metalloproteinases (MMPs) contribute to the destruction of the
extracellular matrix at the shoulder regions of atherosclerotic plaques that leads to plaque …

Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell
undergoes a series of molecular events that lead to a change in phenotype toward a …

Adenoviruses are used extensively as gene transfer agents, both experimentally and
clinically. However, targeting of liver cells by adenoviruses compromises their potential …

Atherosclerosis is a chronic inflammatory disease of the vasculature commonly leading to
myocardial infarction and stroke. We show that IL-33, which is a novel IL-1–like cytokine that …

Matrix metalloproteinase (MMPs) enzymes are implicated in matrix remodelling during
proliferative inflammatory processes including wound healing. We report here synergistic …

Tissue inhibitors of metalloproteinases (TIMPs) are a family of closely related secreted
proteins that limit matrix metalloproteinase (MMP) activity and also have direct effects on cell …

Hypertension is a heritable and major contributor to the global burden of disease. The sum
of rare and common genetic variants robustly identified so far explain only 1%–2% of the …

Background—Diabetes mellitus impairs endothelial cell (EC) function and postischemic
reparative neovascularization by molecular mechanisms that are not fully understood …

Fruits and vegetables are important components of a healthy diet, but intakes in most
Western countries are well below the recommended five servings a day. Men in particular …