OBJECTIVES: To evaluate the clinical effectiveness, safety, tolerability and cost-
effectiveness of etanercept and efalizumab for the treatment of moderate to severe chronic …

The aim of this review was to examine the clinical effectiveness, tolerability and cost-
effectiveness of newer drugs for epilepsy in adults. For the purposes of this review newer …

Objectives: To evaluate the effectiveness of interventions aiming to reduce time from onset of
signs and symptoms of an acute myocardial infarction (AMI) to seeking medical help/arrival …

Examined the effects of water intake on performance in rapid visual information processing
(RVIP) tasks. 60 individuals (mean age 26 yrs) consumed nothing, a small amount, or a …

Mammalian developmental and disease-associated genes concentrate large quantities of
the transcriptional machinery by forming membrane-less compartments known as …

Transcriptional induction of heat shock protein (HSP) genes is accompanied by dynamic
changes in their 3D structure and spatial organization, yet the molecular basis for these …

Specialized mechanisms ensure proper expression of critically important genes such as
those specifying cell identity or conferring protection from environmental stress …

Mediator is an evolutionarily conserved coactivator complex essential for RNA polymerase II
transcription. Although it has been generally assumed that in Saccharomyces cerevisiae …

ABSTRACT Three-dimensional (3D) chromatin organization is important for proper gene
regulation, yet how the genome is remodeled in response to stress is largely unknown …

Essential workers, those who work in a variety of sectors that are critical to sustain the
societal infrastructure, were affected both physically and mentally by the COVID-19 …