Abstract Indoleamine 2, 3-dioxygenase (IDO) is an enzyme that degrades the essential
amino acid tryptophan. The concept that cells expressing IDO can suppress T-cell …

Tumors arise from normal cells of the body through genetic mutation. Although such genetic
mutation often leads to the expression of abnormal antigens, the immune system fails to …

Sustained access to nutrients is a fundamental biological need, especially for proliferating
cells, and controlling nutrient supply is an ancient strategy to regulate cellular responses to …

In 1953 Medawar pointed out that survival of the genetically disparate (allogeneic)
mammalian conceptus contradicts the laws of tissue transplantation. Rapid T cell–induced …

We have recently shown that expression of the enzyme indoleamine 2, 3-dioxygenase (IDO)
during murine pregnancy is required to prevent rejection of the allogeneic fetus by maternal …

BACKGROUND: Schizophrenia is associated with immune system dysfunction, including
aberrant cytokine levels. We performed a meta-analysis of these associations, considering …

One mechanism contributing to immunologic unresponsiveness toward tumors may be
presentation of tumor antigens by tolerogenic host APCs. We show that mouse tumor …

Summary Indoleamine 2, 3 dioxygenase (IDO) catabolizes the amino acid tryptophan. IDO-
expressing immunoregulatory dendritic cells (DCs) have been implicated in settings …

Untitled Page 1 Page 2 ROMANTICISM 8!GENDER Page 3 ROMANTICISM & GENDER
ANNE K. MELLOR I~ ~~o~!~~n~~~up NEW YORK AND LONDON Page 4 Published in 1993 …

Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of
human APCs that express indoleamine 2, 3-dioxygenase (IDO) and inhibit T cell …