The localization and control of Bcl-2 proteins on mitochondria is essential for the intrinsic
pathway of apoptosis. Anti-apoptotic Bcl-2 proteins reside on the outer mitochondrial …

Anoikis is apoptosis induced by loss of cell adhesion or inappropriate cell adhesion.
Adhesion on the extracellular matrix is important to determine whether a cell is in the correct …

VINCULIN, a prominent cytoskeletal protein at cell–substrate adhesions (focal adhesions)
and cell–cell adhesions (adherens junctions) 1, interacts with other cytoskeletal proteins …

It has been proposed that the focal adhesion kinase (FAK) mediates focal adhesion
formation through tyrosine phosphorylation during cell adhesion. We investigated the role of …

Most normal cells require adhesion to extracellular matrix for survival, but the molecular
mechanisms that link cell surface adhesion events to the intracellular apoptotic machinery …

The proapoptotic activity of the “BH3-only” molecule BAD can be differentially regulated by
survival factor signaling. Bad-deficient mice lacking both BAD long and BAD short proteins …

Summary The proapoptotic Bcl-2 protein Bax is predominantly found in the cytosol of
nonapoptotic cells and is commonly thought to translocate to mitochondria following an …

Focal adhesions provide a useful model for studying cell/extracellular matrix interactions
and the subsequent cytoskeletal reorganization. Recent advances have suggested potential …

We have determined the sequence of chicken talin (2,541 amino acids, M r 271,881) which
is very similar (89% identity) to that of the mouse protein. Alignments with the …

Novel cancer chemotherapeutics are required to induce apoptosis by activating pro-
apoptotic proteins. Both epidermal growth factor (EGF) and insulin-like growth factor (IGF) …