Genetically modified crops: current status and future prospects
Main conclusion While transgenic technology has heralded a new era in crop improvement,
several concerns have precluded their widespread acceptance. Alternative technologies …
several concerns have precluded their widespread acceptance. Alternative technologies …
[PDF][PDF] Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization
Macrophage polarization involves a coordinated metabolic and transcriptional rewiring that
is only partially understood. By using an integrated high-throughput transcriptional …
is only partially understood. By using an integrated high-throughput transcriptional …
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
R Possemato, KM Marks, YD Shaul, ME Pacold, D Kim… - Nature, 2011 - nature.com
Cancer cells adapt their metabolic processes to drive macromolecular biosynthesis for rapid
cell growth and proliferation,. RNA interference (RNAi)-based loss-of-function screening has …
cell growth and proliferation,. RNA interference (RNAi)-based loss-of-function screening has …
Clinical consensus guideline on the management of phaeochromocytoma and paraganglioma in patients harbouring germline SDHD pathogenic variants
Patients with germline SDHD pathogenic variants (encoding succinate dehydrogenase
subunit D; ie, paraganglioma 1 syndrome) are predominantly affected by head and neck …
subunit D; ie, paraganglioma 1 syndrome) are predominantly affected by head and neck …
[PDF][PDF] Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer
Accelerated glucose metabolism is a common feature of cancer cells. Hexokinases catalyze
the first committed step of glucose metabolism. Hexokinase 2 (HK2) is expressed at high …
the first committed step of glucose metabolism. Hexokinase 2 (HK2) is expressed at high …
High-Specific-Activity-131I-MIBG versus 177Lu-DOTATATE Targeted Radionuclide Therapy for Metastatic Pheochromocytoma and Paraganglioma
Targeted radionuclide therapies (TRT) using 131I-metaiodobenzylguanidine (131I-MIBG)
and peptide receptor radionuclide therapy (177Lu or 90Y) represent several of the …
and peptide receptor radionuclide therapy (177Lu or 90Y) represent several of the …
[PDF][PDF] Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer
SM Davidson, T Papagiannakopoulos, BA Olenchock… - Cell metabolism, 2016 - cell.com
Cultured cells convert glucose to lactate, and glutamine is the major source of tricarboxylic
acid (TCA)-cycle carbon, but whether the same metabolic phenotype is found in tumors is …
acid (TCA)-cycle carbon, but whether the same metabolic phenotype is found in tumors is …
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
Cancer cells engage in a metabolic program to enhance biosynthesis and support cell
proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered …
proliferation. The regulatory properties of pyruvate kinase M2 (PKM2) influence altered …
Statistical coil model of the unfolded state: resolving the reconciliation problem
An unfolded state ensemble is generated by using a self-avoiding statistical coil model that
is based on backbone conformational frequencies in a coil library, a subset of the Protein …
is based on backbone conformational frequencies in a coil library, a subset of the Protein …
Design and application of the CSRR-based planar sensor for noninvasive measurement of complex permittivity
A novel microwave noninvasive planar sensor based on the complementary split ring
resonator (CSRR) is proposed for an accurate measurement of the complex permittivity of …
resonator (CSRR) is proposed for an accurate measurement of the complex permittivity of …