Formation of the building plan of the human heart: morphogenesis, growth, and differentiation
A Sizarov, J Ya, BA de Boer, WH Lamers… - Circulation, 2011 - Am Heart Assoc
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Molecular analysis of patterning of conduction tissues in the developing human heart
A Sizarov, HD Devalla, RH Anderson… - Circulation …, 2011 - Am Heart Assoc
Background—Recent studies in experimental animals have revealed some molecular
mechanisms underlying the differentiation of the myocardium making up the conduction …
mechanisms underlying the differentiation of the myocardium making up the conduction …
[HTML][HTML] Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice
WTJ Aanhaanen, BJD Boukens… - The Journal of …, 2011 - Am Soc Clin Investig
Ventricular preexcitation, a feature of Wolff-Parkinson-White syndrome, is caused by
accessory myocardial pathways that bypass the annulus fibrosus. This condition increases …
accessory myocardial pathways that bypass the annulus fibrosus. This condition increases …
Three‐dimensional and molecular analysis of the arterial pole of the developing human heart
Labeling experiments in chicken and mouse embryos have revealed important roles for
different cell lineages in the development of the cardiac arterial pole. These data can only …
different cell lineages in the development of the cardiac arterial pole. These data can only …
Three-dimensional and molecular analysis of the venous pole of the developing human heart
A Sizarov, RH Anderson, VM Christoffels… - Circulation, 2010 - Am Heart Assoc
Background—Various congenital malformations and many abnormal rhythms originate from
the venous pole of the heart. Because of rapid changes during morphogenesis, lack of …
the venous pole of the heart. Because of rapid changes during morphogenesis, lack of …
Impairment of the tRNA-splicing endonuclease subunit 54 (tsen54) gene causes neurological abnormalities and larval death in zebrafish models of pontocerebellar …
PR Kasher, Y Namavar, P van Tijn… - Human molecular …, 2011 - academic.oup.com
Pontocerebellar hypoplasia (PCH) represents a group (PCH1–6) of neurodegenerative
autosomal recessive disorders characterized by hypoplasia and/or atrophy of the …
autosomal recessive disorders characterized by hypoplasia and/or atrophy of the …
A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy
MAJ Weterman, V Sorrentino, PR Kasher… - Human molecular …, 2012 - academic.oup.com
Despite the high number of genes identified in hereditary polyneuropathies/Charcot–Marie–
Tooth (CMT) disease, the genetic defect in many families is still unknown. Here we report the …
Tooth (CMT) disease, the genetic defect in many families is still unknown. Here we report the …
Valve interventions in utero: understanding the timing, indications, and approaches
A Sizarov, Y Boudjemline - Canadian Journal of Cardiology, 2017 - Elsevier
Efficient use of fetal echocardiography has enabled early detection of congenital heart
disease and of its often irreversible complications, such as ventricular hypoplasia in case of …
disease and of its often irreversible complications, such as ventricular hypoplasia in case of …
Safety and feasibility of the transcatheter approach to create a reverse Potts shunt in children with idiopathic pulmonary arterial hypertension
Y Boudjemline, A Sizarov, S Malekzadeh-Milani… - Canadian Journal of …, 2017 - Elsevier
Abstract Background The reversed Potts shunt improves right ventricular (RV) function in
patients with suprasystemic pulmonary arterial hypertension (PAH). The proximity of the left …
patients with suprasystemic pulmonary arterial hypertension (PAH). The proximity of the left …
Development of the human aortic arch system captured in an interactive three‐dimensional reference model
MS Rana, A Sizarov, VM Christoffels… - American journal of …, 2014 - Wiley Online Library
Variations and mutations in the human genome, such as 22q11. 2 microdeletion, can
increase the risk for congenital defects, including aortic arch malformations. Animal models …
increase the risk for congenital defects, including aortic arch malformations. Animal models …