User profiles for "author:Andrew Wragg"

Andrew Wragg

Barts Heart Centre
Verified email at bartshealth.nhs.uk
Cited by 10623

p53 regulates mitochondrial respiration

S Matoba, JG Kang, WD Patino, A Wragg, M Boehm… - Science, 2006 - science.org
The energy that sustains cancer cells is derived preferentially from glycolysis. This metabolic
change, the Warburg effect, was one of the first alterations in cancer cells recognized as …

A rapid protocol for the prevention of contrast-induced renal dysfunction: the RAPPID study

CSR Baker, A Wragg, S Kumar, R De Palma… - Journal of the American …, 2003 - jacc.org
Objectives: This study was designed to test a rapid protocol of intravenous acetylcysteine for
prevention of radiocontrast-induced nephropathy (RCIN). Background: Oral acetylcysteine …

TGF-β signaling mediates endothelial-to-mesenchymal transition (EndMT) during vein graft remodeling

BC Cooley, J Nevado, J Mellad, D Yang… - Science translational …, 2014 - science.org
Veins grafted into an arterial environment undergo a complex vascular remodeling process.
Pathologic vascular remodeling often results in stenosed or occluded conduit grafts …

Implementing workplace‐based assessment across the medical specialties in the United Kingdom

JR Wilkinson, JGM Crossley, A Wragg, P Mills… - Medical …, 2008 - Wiley Online Library
Objectives To evaluate the reliability and feasibility of assessing the performance of medical
specialist registrars (SpRs) using three methods: the mini‐clinical evaluation exercise (mini …

Successful recanalization of chronic total occlusions is associated with improved long-term survival

DA Jones, R Weerackody, K Rathod, J Behar… - JACC: Cardiovascular …, 2012 - jacc.org
Objectives: This study investigated the impact of procedural success on mortality following
chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in a large cohort of …

Learning systems: managing uncertainty in the new normal of Covid-19

R Bohmer, J Shand, D Allwood, A Wragg… - … Innovations in Care …, 2020 - catalyst.nejm.org
The novel coronavirus has presented considerable challenges to clinicians. In London,
leaders employed a “learning system” model to quickly create and refine a care delivery …

[HTML][HTML] A prospective international multicentre cohort study of intraoperative heart rate and systolic blood pressure and myocardial injury after noncardiac surgery …

TEF Abbott, RM Pearse, RA Archbold… - Anesthesia & …, 2018 - journals.lww.com
BACKGROUND: The association between intraoperative cardiovascular changes and
perioperative myocardial injury has chiefly focused on hypotension during noncardiac …

Acute myocarditis presenting as acute coronary syndrome: role of early cardiac magnetic resonance in its diagnosis

PA Monney, N Sekhri, T Burchell, C Knight, C Davies… - Heart, 2011 - heart.bmj.com
Background In patients presenting with acute cardiac symptoms, abnormal ECG and raised
troponin, myocarditis may be suspected after normal angiography. Aims To analyse cardiac …

Integrating CT myocardial perfusion and CT-FFR in the work-up of coronary artery disease

A Coenen, A Rossi, MM Lubbers, A Kurata… - JACC: Cardiovascular …, 2017 - jacc.org
Objectives: The aim of this study was to investigate the individual and combined accuracy of
dynamic computed tomography (CT) myocardial perfusion imaging (MPI) and computed …

Diagnostic performance of hyperaemic myocardial blood flow index obtained by dynamic computed tomography: does it predict functionally significant coronary …

A Rossi, A Dharampal, A Wragg… - European Heart …, 2014 - academic.oup.com
Aims The severity of coronary artery narrowing is a poor predictor of functional significance,
in particular in intermediate coronary lesions (30–70% diameter narrowing). The aim of this …