Calcium and Ca 2+-dependent signals play a crucial role in sperm motility and mammalian
fertilization, but the molecules and mechanisms underlying these Ca 2+-dependent …

The cell-surface glycoprotein CD36 interacts with a large variety of ligands, including
collagen types I and IV, thrombospondin, erythrocytes parasitized with Plasmodium …

Most of the gemcitabine (dFdC) resistant cell lines manifested high NFκB activity. The NFκB
activity can be induced by dFdC and 5-FU exposure. The chemosensitizing effect of …

Multidrug resistance in acute myeloid leukemia is often conferred by overexpression of P-
glycoprotein, encoded by the MDR1 gene. We have characterized the key regulatory steps …

Breast cancer stem cells (BCSCs) are pan-resistant to different anticancer agents and
responsible for cancer relapse. Disulfiram (DS), an antialcoholism drug, targets CSCs and …

The main role of the plasma membrane Ca 2+/calmodulin-dependent ATPase (PMCA) is in
the removal of Ca 2+ from the cytosol. Recently, we and others have suggested a new …

Background—Neuronal nitric oxide synthase (nNOS) has recently been shown to be a major
regulator of cardiac contractility. In a cellular system, we have previously shown that nNOS is …

Angiogenesis requires co-ordination of multiple signalling inputs to regulate the behaviour
of endothelial cells (ECs) as they form vascular networks. Vascular endothelial growth factor …

Plasma membrane calmodulin-dependent calcium ATPases (PMCAs) are enzymatic
systems implicated in the extrusion of calcium from the cell. We and others have previously …

The anticancer activity of disulfiram (DS) is copper (ii)(Cu)-dependent. This study
investigated the anticancer mechanisms of DS/Cu using in vitro cytotoxicity and metabolic …