One Japanese pedigree of familial essential thrombocythemia (FET) inherited in an
autosomal-dominant manner is presented. A unique point mutation, serine 505 to …

A new compound named eucamalol and 4-isopropylbenzyl alcohol were isolated as
mosquito repellents from the essential oil of Eucalyptus camaldulensis. The structure of …

Abstract Background The Trastuzumab for Gastric Cancer (ToGA) study is the first
international trial to include Japanese patients with human epidermal growth factor 2 …

We identified 4-fluoro-N-[4-[6-(isopropylamino) pyrimidin-4-yl]-1, 3-thiazol-2-yl]-N-
methylbenzamide 27 as a potent mGluR1 antagonist. The compound possessed excellent …

Objective: To investigate associations between socioeconomic status (SES) and prevalence,
awareness, treatment, and control of hypertension in Japan's general population. Methods …

BACKGROUND The goal of the current study was to evaluate the objective response rate
and toxicity associated with the oral fluoropyrimidine S‐1 (a combination of tegafur, 5‐chloro …

We describe here the discovery and biological profile of a series of isoindolinone derivatives
as developed mGluR1 antagonists. Our combined strategy of rapid parallel synthesis and …

Background The mechanisms by which exercise reduces the risk of coronary heart disease
remain poorly understood. Irisin, an exercise-induced polypeptide secreted from skeletal …

We describe here the discovery and the structure–activity relationship (SAR) of a series of 4-
(1-Aryltriazol-4-yl)-tetrahydropyridines as novel mGluR1 antagonists. Our extensive …

Objectives This study aimed to clarify the relationship between the white blood cell (WBC)
count and hypertension in the general Japanese population. Methods We conducted a …