Insulin resistance has been proposed as a mediator of the association between risk factors
for cardiovascular disease in the population. The clinical syndrome of glucocorticoid excess …

Abstract 11β-hydroxysteroid dehydrogenases (11β-HSDs) catalyze the interconversion of
active glucocorticoids (cortisol, corticosterone) and inert 11-keto forms (cortisone, 11 …

Recent studies have shown that reduced fetal growth is associated with the development of
the insulin resistance syndrome in adult life. The mechanisms are not known. However …

Cortisol has been implicated as a pathophysiological mediator in idiopathic obesity, but
circulating cortisol concentrations are not consistently elevated. The tissue-specific …

Background—The causes of metabolic syndrome (MS), which may be a precursor of
coronary disease, are uncertain. We hypothesize that disturbances in neuroendocrine and …

Background: Glucocorticoids have adverse systemic effects, including obesity, hypertension,
and hyperglycemia, that may predispose to cardiovascular disease. The effect of …

The metabolic syndrome (visceral obesity, insulin resistance, type 2 diabetes, and
dyslipidemia) resembles Cushing's Syndrome, but without elevated circulating …

Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in
observational studies is reproducibly associated with future risk of adult metabolic diseases …

Fuelled by the obesity epidemic, there is considerable interest in the developmental origins
of white adipose tissue (WAT) and the stem and progenitor cells from which it arises …

Cushing's syndrome and the metabolic syndrome share clinical similarities. Reports of
alterations in the hypothalamic-pituitary-adrenal (HPA) axis are inconsistent, however, in the …