Aims Gut microbiota-derived metabolite trimethylamine-N-oxide (TMAO) is emerging as a
new potentially important cause of increased cardiovascular risk. The purpose of this meta …

Clinical and epidemiological studies demonstrate that short-and long-term exposure to air
pollution increases mortality due to respiratory and cardiovascular diseases. Given the …

Importance The outcomes of patients with left ventricular (LV) dysfunction and secondary
mitral regurgitation (SMR) are still controversial. Objective To clarify the role of SMR in the …

Background In cross-sectional studies, ambulatory blood pressure (ABP) correlates more
closely than clinic BP with the organ damage of hypertension. Whether ABP predicts …

Recent evidence suggests that besides its action on the central nervous system, leptin can
modulate vascular tone through local mechanisms involving nitric oxide (NO) release. In this …

In this study, we reveal that leptin evokes an acute hypotensive effect in 6-hydroxydopamine
sympathectomized rats (response to maximal leptin dose, mean blood pressure: from 92+/-4 …

Background—Left ventricular hypertrophy (LVH) represents both an adaptive response to
increased cardiac work load and a precursor state of heart failure. Recent evidence linked …

Modulating angiogenesis is an attractive goal because many pathological conditions
depend on the growth of new vessels. Angiogenesis is mainly regulated by the VEGF, a …

Objectives: The purpose of this paper was to assess whether statins reduce all-cause
mortality and cardiovascular (CV) events in elderly people without established CV disease …

The reason why hyperinsulinemia is associated with essential hypertension is not known. To
test the hypothesis of a pathophysiologic link mediated by the sympathetic nervous system …