Language and communication development in Down syndrome

JE Roberts, J Price, C Malkin - Mental retardation and …, 2007 - Wiley Online Library
Although there is considerable variability, most individuals with Down syndrome have
mental retardation and speech and language deficits, particularly in language production …

Androgens, insulin resistance and vascular disease in men

D Kapoor, CJ Malkin, KS Channer… - Clinical …, 2005 - Wiley Online Library
Type 2 diabetes mellitus is increasing globally and is an established risk factor for the
development of atherosclerotic vascular disease. Insulin resistance is the hallmark feature of …

Testosterone as a protective factor against atherosclerosis--immunomodulation and influence upon plaque development and stability.

CJ Malkin, PJ Pugh, RD Jones, TH Jones… - The Journal of …, 2003 - europepmc.org
Inflammation plays a central pathogenic role in the initiation and progression of coronary
atheroma and its clinical consequences. Cytokines are the mediators of cellular …

The effect of testosterone replacement on endogenous inflammatory cytokines and lipid profiles in hypogonadal men

CJ Malkin, PJ Pugh, RD Jones, D Kapoor… - The Journal of …, 2004 - academic.oup.com
Testosterone has immune-modulating properties, and current in vitro evidence suggests that
testosterone may suppress the expression of the proinflammatory cytokines TNFα, IL-1β …

Testosterone therapy in men with moderate severity heart failure: a double-blind randomized placebo controlled trial

CJ Malkin, PJ Pugh, JN West… - European heart …, 2006 - academic.oup.com
Aims Chronic heart failure is associated with maladaptive and prolonged neurohormonal
and pro-inflammatory cytokine activation causing a metabolic shift favouring catabolism …

Testosterone replacement in hypogonadal men with angina improves ischaemic threshold and quality of life

CJ Malkin, PJ Pugh, PD Morris, KE Kerry, RD Jones… - Heart, 2004 - heart.bmj.com
Background: Low serum testosterone is associated with several cardiovascular risk factors
including dyslipidaemia, adverse clotting profiles, obesity, and insulin resistance …

Low serum testosterone and increased mortality in men with coronary heart disease

CJ Malkin, PJ Pugh, PD Morris, S Asif, TH Jones… - Heart, 2010 - heart.bmj.com
Background To examine the effect of serum testosterone levels on survival in a consecutive
series of men with confirmed coronary disease and calculate the prevalence of testosterone …

Long-term durability of transcatheter aortic valve prostheses

DJ Blackman, S Saraf, PA MacCarthy, A Myat… - Journal of the American …, 2019 - jacc.org
Background: Very little is known about long-term valve durability after transcatheter aortic
valve replacement (TAVR). Objectives: This study sought to evaluate the incidence of …

Clinical outcomes with a repositionable self-expanding transcatheter aortic valve prosthesis: the international FORWARD study

E Grube, NM Van Mieghem, S Bleiziffer… - Journal of the American …, 2017 - jacc.org
Background: Clinical outcomes in large patient populations from real-world clinical practice
with a next-generation self-expanding transcatheter aortic valve are lacking. Objectives: This …

Long-term benefits of testosterone replacement therapy on angina threshold and atheroma in men

A Mathur, C Malkin, B Saeed… - European Journal of …, 2009 - academic.oup.com
Introduction In short-term studies, testosterone replacement therapy has been shown to
protect male subjects from exercise-induced ischaemia and modify cardiovascular risk …