Block of activated and inactivated sodium channels by class-I antiarrhythmic drugs studied by using the maximum upstroke velocity (Vmax) of action potential in …

I Kodama, J Toyama, C Takanaka, K Yamada - Journal of Molecular and …, 1987 - Elsevier
The inhibitory effect of disopyramide, quinidine, mexiletine, lidocaine, tocainide and
aprindine on the maximum upstroke velocity (V̇ max) of action potential was examined in …

Transient giant negative T wave in acute anterior myocardial infarction predicts R wave recovery and preservation of left ventricular function.

…, M Hirai, H Hirayama, A Suzuki, C Takanaka… - Heart, 1996 - heart.bmj.com
OBJECTIVE: To investigate the value of a giant negative T wave (> or= 1.0 mV) in precordial
leads of 12-lead electrocardiograms in the acute phase of Q wave myocardial infarction as a …

Barium-induced nondriven action potentials as a model of triggered potentials from early afterdepolarization: Significance of slow channel activity and differeing effects …

C Takanaka, BN Singh - Journal of the American College of Cardiology, 1990 - Elsevier
Triggered activity due to early afterdepolarizations in the content of prolonged repolarization
is believed to cause torsade de pointes. The nature of such triggered activity is not clearly …

Electrophysiologic effects of ambasilide (LU 47110), a novel class III antiarrhythmic agent, on the properties of isolated rabbit and canine cardiac muscle

C Takanaka, JSM Sarma, BN Singh - Journal of cardiovascular …, 1992 - journals.lww.com
Electrophysiologic effects of ambasilide in canine isolated cardiac muscle driven at 1 Hz and
in rabbit sinoatrial (SA) node preparations were determined by standard microelectrode …

Antiarrhythmic and arrhythmogenic actions of varying levels of extracellular magnesium: possible cellular basis for the differences in the efficacy of magnesium and …

C Takanaka, KO Ogunyankin… - Journal of …, 1997 - journals.sagepub.com
Background: In recent years, there has been an increasing use of antiarrhythmic drugs that
act predominantly by prolonging myocardial repolarization. An inevitable electrophysiologic …

Machine learning-based detection of sleep-disordered breathing in hypertrophic cardiomyopathy

…, K Ohno, M Kamakura, R Nawada, C Takanaka… - Heart, 2024 - heart.bmj.com
Background Hypertrophic cardiomyopathy (HCM) is often concomitant with sleep-disordered
breathing (SDB), which can cause adverse cardiovascular events. Although an appropriate …

Mexiletine and propafenone: a comparative study of monotherapy, low, and full dose combination therapy

C Takanaka, M Nonokawa, T Machii… - Pacing and Clinical …, 1992 - Wiley Online Library
The electrophysiological effects of combination therapy of mexiletine and propafenone were
assessed using standard 12‐Iead electrocardiogram (standard ECG), signal‐averaged EGG …

Frequency dependent effects of class I antiarrhythmic agents studied in patients with implanted pacemakers

C Takanaka, JK Lee, M Nonokawa… - Pacing and Clinical …, 1994 - Wiley Online Library
Use and frequency dependency are common properties of Class I antiarrhythmic agents,
which block cardiac sodium channels in vitro. The purpose of this study was to examine the …

Surgical repair of a pseudoaneurysm derived from a nine-year-old saphenous vein graft after coronary artery bypass

…, T Hiraiwa, H Hata, C Takanaka - The Japanese Journal of …, 2002 - Springer
A 57-year-old male presented intermittent pain between the left shoulder and neck. He had
undergone coronary artery bypass twice and all grafts had been confirmed to be …

Novel extrathoracic puncture techniques for pacemaker lead insertion: Pitfalls of the conventional extrathoracic puncture method

…, M Kobayashi, M Saito, C Takanaka… - journal of …, 2012 - Wiley Online Library
Introduction Surgical procedures for pacemaker implantation vary among facilities. The
extrathoracic venous puncture method has been utilized for lead insertion, although patients' …