The cystine knot motif in toxins and implications for drug design
The cystine knot structural motif is present in peptides and proteins from a variety of species,
including fungi, plants, marine molluscs, insects and spiders. It comprises an embedded ring …
including fungi, plants, marine molluscs, insects and spiders. It comprises an embedded ring …
Plant cyclotides: a unique family of cyclic and knotted proteins that defines the cyclic cystine knot structural motif
Several macrocyclic peptides (∼ 30 amino acids), with diverse biological activities, have
been isolated from the Rubiaceae and Violaceae plant families over recent years. We have …
been isolated from the Rubiaceae and Violaceae plant families over recent years. We have …
Biosynthesis and insecticidal properties of plant cyclotides: The cyclic knotted proteins from Oldenlandia affinis
C Jennings, J West, C Waine… - Proceedings of the …, 2001 - National Acad Sciences
Several members of the Rubiaceae and Violaceae families produce a series of cyclotides or
macrocyclic peptides of 29–31 amino acids with an embedded cystine knot. We aim to …
macrocyclic peptides of 29–31 amino acids with an embedded cystine knot. We aim to …
[HTML][HTML] Twists, knots, and rings in proteins: structural definition of the cyclotide framework
KJ Rosengren, NL Daly, MR Plan, C Waine… - Journal of Biological …, 2003 - ASBMB
In recent years an increasing number of miniproteins containing an amide-cyclized
backbone have been discovered. The cyclotide family is the largest group of such proteins …
backbone have been discovered. The cyclotide family is the largest group of such proteins …
Isolation, Solution Structure, and Insecticidal Activity of Kalata B2, a Circular Protein with a Twist: Do Möbius Strips Exist in Nature?,
A large number of macrocyclic miniproteins with diverse biological activities have been
isolated from the Rubiaceae, Violaceae, and Cucurbitaceae plant families in recent years …
isolated from the Rubiaceae, Violaceae, and Cucurbitaceae plant families in recent years …
[HTML][HTML] Conserved structural and sequence elements implicated in the processing of gene-encoded circular proteins
JL Dutton, RF Renda, C Waine, RJ Clark… - Journal of Biological …, 2004 - ASBMB
The cyclotides are the largest family of naturally occurring circular proteins. The mechanism
by which the termini of these gene-encoded proteins are linked seamlessly with a peptide …
by which the termini of these gene-encoded proteins are linked seamlessly with a peptide …
Nutrition and the health care agenda: a primary care perspective
H Moore, AJ Adamson, T Gill, C Waine - Family Practice, 2000 - academic.oup.com
The current climate of prioritizing in the NHS brings into focus the debate surrounding
efficient and effective management of conditions associated with the modern lifestyle. In any …
efficient and effective management of conditions associated with the modern lifestyle. In any …
Best practice in primary care pathology: review 3
…, SRS Smart, TM Reynolds, C Waine - Journal of clinical …, 2006 - jcp.bmj.com
This best practice review examines four series of common primary care questions in
laboratory medicine:(i)“minor” blood platelet count and haemoglobin abnormalities;(ii) …
laboratory medicine:(i)“minor” blood platelet count and haemoglobin abnormalities;(ii) …
[BOOK][B] Obesity and weight management in primary care
C Waine, N Bosanquet - 2008 - books.google.com
Obesity is undoubtedly the major nutritional disorder of the western world. It has such a
major impact on mortality, morbidity and the quality of life that it most certainly merits …
major impact on mortality, morbidity and the quality of life that it most certainly merits …
Aphicidal efficacy of scorpion-and spider-derived neurotoxins
Insect-specific neurotoxins that act within the insect hemocoel (body cavity) represent an
untapped resource for insect pest management. On the basis of recent advances made in …
untapped resource for insect pest management. On the basis of recent advances made in …