[HTML][HTML] Hypertension and chronic ethanol consumption: what do we know after a century of study?

KC Marchi, JJ Muniz, CR Tirapelli - World journal of cardiology, 2014 - ncbi.nlm.nih.gov
The influences of life habits on the cardiovascular system may have important implications
for public health, as cardiovascular diseases are among the leading causes of shorter life …

Effects of melatonin on thymic and oxidative stress dysfunctions during Trypanosoma cruzi infection

V Brazão, RP Colato, FH Santello… - Journal of Pineal …, 2018 - Wiley Online Library
Although the exact etiology of Chagas disease is not completely elucidated, thymic atrophy
and oxidative stress are believed to be important contributors to the pathogenesis during …

Benefits of ascorbic acid in association with low-dose benznidazole in treatment of Chagas disease

MV Providello, ZA Carneiro, GB Portapilla… - Antimicrobial agents …, 2018 - Am Soc Microbiol
The acute phase of Chagas disease (CD) is characterized by high parasitic proliferation and
intense inflammation, exacerbating the generation of reactive oxygen species (ROS) and …

NADPH oxidase plays a role on ethanol-induced hypertension and reactive oxygen species generation in the vasculature

KC Marchi, CS Ceron, JJ Muniz… - Alcohol and …, 2016 - academic.oup.com
Aims Investigate the role of NADPH oxidase on ethanol-induced hypertension and vascular
oxidative stress. Methods Male Wistar rats were treated with ethanol (20% v/v). Results …

Chronic ethanol consumption compromises neutrophil function in acute pulmonary Aspergillus fumigatus infection

NLSO Malacco, JAM Souza, FRB Martins, MA Rachid… - Elife, 2020 - elifesciences.org
Chronic ethanol consumption is a leading cause of mortality worldwide, with higher risks to
develop pulmonary infections, including Aspergillus infections. Mechanisms underlying …

[HTML][HTML] Vascular injury associated with ethanol intake is driven by AT1 receptor and mitochondrial dysfunction

WMC Awata, JV Alves, RM Costa… - Biomedicine & …, 2023 - Elsevier
Abstract Background Renin-angiotensin (Ang II)-aldosterone system (RAAS) is crucial for
the cardiovascular risk associated with excessive ethanol consumption. Disturbs in …

Pyrrolidine dithiocarbamate down‐regulates vascular matrix metalloproteinases and ameliorates vascular dysfunction and remodelling in renovascular hypertension

SBA Cau, DA Guimarães, E Rizzi… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE Mounting evidence implicates matrix metalloproteinase
(MMP) in the vascular dysfunction and remodelling associated with hypertension. We tested …

Melatonin regulates antioxidant defense and inflammatory response by activating Nrf2–dependent mechanisms and inhibiting NFkappaB expression in middle-aged T …

V Brazão, RP Colato, FH Santello, A Duarte… - Experimental …, 2022 - Elsevier
Oxidative stress with higher levels of leptin and inflammatory response are key processes
related to pathogenesis of both T. cruzi infection and aging. Nuclear factor erythroid 2 …

[HTML][HTML] Kaurene diterpene induces apoptosis in U87 human malignant glioblastoma cells by suppression of anti-apoptotic signals and activation of cysteine …

FS Lizarte Neto, DPC Tirapelli, SR Ambrosio… - Brazilian Journal of …, 2013 - SciELO Brasil
Gliomas are the most common and malignant primary brain tumors in humans. Studies have
shown that classes of kaurene diterpene have anti-tumor activity related to their ability to …

[HTML][HTML] Bipolar affective disorder: pharmacotherapeutic profile and adherence to medication

AI Miasso, BP Carmo, CR Tirapelli - Revista da Escola de …, 2012 - SciELO Brasil
This cross-sectional and descriptive study aimed to verify the adherence of patients with
Bipolar Affective Disorder (BAD) to medication and to identify possible causes of adherence …