[HTML][HTML] Netrin family: Role for protein isoforms in cancer

CS Bruikman, H Zhang, AM Kemper… - Journal of nucleic …, 2019 - hindawi.com
Netrins form a family of secreted and membrane-associated proteins. Netrins are involved in
processes for axonal guidance, morphogenesis, and angiogenesis by regulating cell …

Molecular basis of familial hypercholesterolemia

CS Bruikman, GK Hovingh… - Current opinion in …, 2017 - journals.lww.com
The phenotype of familial hypercholesterolemia is caused by more than 1700 mutations the
LDLR, apoB and PCSK9 genes, which explains approximately 85% of familial …

[HTML][HTML] Understanding netrins and semaphorins in mature endothelial cell biology

H Zhang, D Vreeken, CS Bruikman… - Pharmacological …, 2018 - Elsevier
Netrins and semaphorins are known as neuronal guidance molecules that are important to
the facilitate patterning of the nervous system in embryonic development. In recent years …

Netrin-1 and the grade of atherosclerosis are inversely correlated in humans

CS Bruikman, D Vreeken, RM Hoogeveen… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Netrin-1 has been shown to play a role in the initiation of atherosclerosis in mice
models. However, little is known about the role of Netrin-1 in humans. We set out to study …

New drugs for atherosclerosis

CS Bruikman, RM Stoekenbroek, GK Hovingh… - Canadian Journal of …, 2017 - Elsevier
Atherosclerosis, the underlying process that ultimately leads to clinical cardiovascular
disease (CVD), is caused by the multifactorial interaction of various conditions, and …

[HTML][HTML] Netrin-4 expression by human endothelial cells inhibits endothelial inflammation and senescence

H Zhang, D Vreeken, DG Leuning, CS Bruikman… - … International Journal of …, 2021 - Elsevier
Netrin-4, recognized in neural and vascular development, is highly expressed by mature
endothelial cells. The function of this netrin-4 in vascular biology after development has …

EPH receptor B2 stimulates human monocyte adhesion and migration independently of its EphrinB ligands

D Vreeken, CS Bruikman, SML Cox… - Journal of Leucocyte …, 2020 - academic.oup.com
The molecular basis of atherosclerosis is not fully understood and mice studies have shown
that Ephrins and EPH receptors play a role in the atherosclerotic process. We set out to …

[HTML][HTML] The identification and function of a Netrin-1 mutation in a pedigree with premature atherosclerosis

CS Bruikman, D Vreeken, H Zhang, MJ van Gils… - Atherosclerosis, 2020 - Elsevier
Background and aims Neuroimmune guidance cues have been shown to play a role in
atherosclerosis, but their exact role in human pathophysiology is largely unknown. In the …

[HTML][HTML] Downregulation of endothelial plexin A4 under inflammatory conditions impairs vascular integrity

D Vreeken, CS Bruikman, W Stam, SML Cox… - Frontiers in …, 2021 - frontiersin.org
Objective: Besides hyperlipidemia, inflammation is an important determinant in the initiation
and the progression of atherosclerosis. As Neuroimmune Guidance Cues (NGCs) are …

Sudden cardiac death in families with premature cardiovascular disease

C Bruikman, MWJ de Ronde, A Amin, S Levy, P Lof… - Heart, 2020 - heart.bmj.com
Objective Sudden cardiac death (SCD) in families with premature atherosclerosis (PAS) is
generally attributed to lethal arrhythmias during myocardial infarction. Yet, such arrhythmias …