The lymphatic vasculature is a blind-ended network crucial for tissue-fluid homeostasis,
immune surveillance and lipid absorption from the gut. Recent evidence has proposed an …

Nickel is an essential metal for a number of bacterial species that have developed systems
for acquiring, delivering, and incorporating the metal into target enzymes and controlling the …

Myocardial infarction (MI) arising from obstruction of the coronary circulation engenders
massive cardiomyocyte loss and replacement by non-contractile scar tissue, leading to …

The heart is a metabolic omnivore and the adult heart selects the substrate best suited for
each circumstance, with fatty acid oxidation preferred in order to fulfill the high energy …

Iron is essential to the cell. Both iron deficiency and overload impinge negatively on cardiac
health. Thus, effective iron homeostasis is important for cardiac function. Ferroportin (FPN) …

Despite great advances in therapy over the past decades, ischemic heart disease (IHD)
remains the leading cause of death worldwide because the decrease in mortality after acute …

Compartmentalized cAMP/PKA signalling is now recognized as important for physiology and
pathophysiology, yet a detailed understanding of the properties, regulation and function of …

Background To study the pathogenesis of diabetic cardiomyopathy, reliable animal models
of type 2 diabetes are required. Physiologically relevant rodent models are needed, which …

Heart failure patients have abnormal cardiac high energy phosphate metabolism, the
explanation for which is unknown. Patients with heart failure also have elevated plasma free …

Although diabetic cardiomyopathy is widely recognized, there are no specific treatments
available. Altered myocardial substrate selection has emerged as a candidate mechanism …