Background The benefits of blood pressure lowering treatment for prevention of
cardiovascular disease are well established. However, the extent to which these effects …

Mendelian randomization uses genetic variants to determine whether an observational
association between a risk factor and an outcome is consistent with a causal effect. 1 …

Importance Lowering blood pressure (BP) is widely used to reduce vascular risk in
individuals with diabetes. Objective To determine the associations between BP–lowering …

Background Both genetic and lifestyle factors contribute to individual-level risk of coronary
artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle …

Abstract Background: Approximately 7% of American adults have severe
hypercholesterolemia (untreated low-density lipoprotein [LDL] cholesterol≥ 190 mg/dl) …

Objective To quantify the association between atrial fibrillation and cardiovascular disease,
renal disease, and death. Design Systematic review and meta-analysis. Data sources …

Abstract The Million Veteran Program (MVP) was established in 2011 as a national research
initiative to determine how genetic variation influences the health of US military veterans …

Importance Observational studies have consistently proposed cardiovascular benefits
associated with light alcohol consumption, while recent genetic analyses (ie, mendelian …

Background: Familial combined hypolipidemia, a Mendelian condition characterized by
substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the …

Objective To determine whether atrial fibrillation is a stronger risk factor for cardiovascular
disease and death in women compared with men. Design Meta-analysis of cohort studies …