Chronic liver diseases are associated with multiple complications, including cirrhosis, portal
hypertension, ascites, synthetic dysfunction and hepatocellular carcinoma, and these …

INTRODUCTION The thymus is the critical organ for T cell development and T cell receptor
(TCR) repertoire formation, which shapes the landscape of adaptive immunity. T cell …

Aims Left atrial appendage closure is a non-pharmacological alternative for stroke
prevention in high-risk patients with non-valvular atrial fibrillation. The objective of the …

Long-term engraftment of allogeneic cells necessitates eluding immune-mediated rejection,
which is currently achieved by matching for human leukocyte antigen (HLA) expression …

Background: Infants born with cardiac abnormalities causing dependence on the arterial
duct for pulmonary blood flow are often palliated with a shunt usually between the …

Background Irbesartan, a long acting selective angiotensin-1 receptor inhibitor, in Marfan
syndrome might reduce aortic dilatation, which is associated with dissection and rupture. We …

Together, heart failure and arrhythmia represent the most important cardiovascular sources
of morbidity and mortality among adults with congenital heart disease (ACHDs). Although …

There is mounting recognition that some of the most urgent problems of adult congenital
heart disease (ACHD) are the prevention, diagnosis, and management of heart failure (HF) …

Objective: To describe our preliminary experience with Levosimendan, a new calcium-
sensitizing agent in critically unwell infants and children with severe heart failure. Design …

Abstract The Sleeping Beauty (SB) transposon/transposase DNA plasmid system is used to
genetically modify cells for long-term transgene expression. We adapted the SB system for …