User profiles for "author:D Hausenloy"

Derek Hausenloy

Professor, University College London and Duke-NUS
Verified email at ucl.ac.uk
Cited by 48886

Myocardial reperfusion injury

DM Yellon, DJ Hausenloy - New England Journal of Medicine, 2007 - Mass Medical Soc
Lethal reperfusion injury is a paradoxical type of myocardial injury caused by the restoration
of coronary blood flow after an ischemic episode. This review focuses on the mechanisms of …

[HTML][HTML] Myocardial ischemia-reperfusion injury: a neglected therapeutic target

DJ Hausenloy, DM Yellon - The Journal of clinical …, 2013 - Am Soc Clin Investig
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In
patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and …

New directions for protecting the heart against ischaemia–reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway

DJ Hausenloy, DM Yellon - Cardiovascular research, 2004 - academic.oup.com
Reperfusion is a pre-requisite to salvaging viable myocardium, following an acute
myocardial infarction. Reperfusion of ischaemic myocardium, however, is not without risk, as …

Postconditioning: a form of “modified reperfusion” protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathway

A Tsang, DJ Hausenloy, MM Mocanu… - Circulation …, 2004 - Am Heart Assoc
Brief intermittent episodes of ischemia and reperfusion, at the onset of reperfusion after a
prolonged period of ischemia, confer cardioprotection, a phenomenon termed “ischemic …

Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury

SB Ong, S Subrayan, SY Lim, DM Yellon… - Circulation, 2010 - Am Heart Assoc
Background—Whether alterations in mitochondrial morphology affect the susceptibility of the
heart to ischemia/reperfusion injury is unknown. We hypothesized that modulating …

Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial

DJ Hausenloy, PK Mwamure, V Venugopal, J Harris… - The Lancet, 2007 - thelancet.com
Background Whether remote ischaemic preconditioning, an intervention in which brief
ischaemia of one tissue or organ protects remote organs from a sustained episode of …

[HTML][HTML] Remote ischemic preconditioning and outcomes of cardiac surgery

DJ Hausenloy, L Candilio, R Evans… - … England Journal of …, 2015 - Mass Medical Soc
Background Whether remote ischemic preconditioning (transient ischemia and reperfusion
of the arm) can improve clinical outcomes in patients undergoing coronary-artery bypass …

Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?

DJ Hausenloy, HL Maddock, GF Baxter… - Cardiovascular …, 2002 - academic.oup.com
Objective: We propose that ischemic preconditioning (IPC) and mitochondrial KATP channel
activation protect the myocardium by inhibiting mitochondrial permeability transition pore …

Remote ischaemic preconditioning: underlying mechanisms and clinical application

DJ Hausenloy, DM Yellon - Cardiovascular research, 2008 - academic.oup.com
Remote ischaemic preconditioning (RIPC) represents a strategy for harnessing the body's
endogenous protective capabilities against the injury incurred by ischaemia and …

Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection

DJ Hausenloy, DM Yellon - Heart failure reviews, 2007 - Springer
Following an acute myocardial infarction (AMI), early coronary artery reperfusion remains
the most effective means of limiting the eventual infarct size. The resultant left ventricular …