Cancer can be defined as a genetic disease, resulting as a consequence of multiple events
associated with initiation, promotion and metastatic growth. Cancer results from the loss of …

Ets is a family of transcription factors present in species ranging from sponges to human. All
family members contain an approximately 85 amino acid DNA binding domain, designated …

The Ets family consists of a large number of evolutionarily conserved transcription factors,
many of which have been implicated in tumor progression. Extensive studies on this family …

We previously demonstrated that the putative oncogene AKT2 is amplified and
overexpressed in some human ovarian carcinomas. We have now identified amplification of …

The Ets family of transcription factors have been suggested to function as key regulators of
hematopoeisis. Here we describe aberrant hematopoeisis and hemorrhaging in mouse …

Ets proteins are a family of transcription factors that share an 85 amino acid conserved DNA
binding domain, the ETS domain. Over 25 mammalian Ets family members control important …

Systemic sclerosis or scleroderma (SSc) is a complex autoimmune connective tissue
disease characterized by obliterative vasculopathy and tissue fibrosis. The molecular …

ETS1 is a member of the evolutionarily conserved family of ets genes, which are
transcription factors that bind to unique DNA sequences, either alone or by association with …

The molecular and cellular mechanisms that maintain proper collagen homeostasis in
healthy human skin and are responsible for the dysregulated collagen synthesis in …

The ETS factor ETV 2 (aka ER 71) is essential for the generation of the blood and vascular
system, as ETV 2 deficiency leads to a complete block in blood and endothelial cell …