The spontaneously hypertensive rat as a model of human cardiovascular disease: evidence of exacerbated cardiopulmonary injury and oxidative stress from inhaled …
UP Kodavanti, MC Schladweiler, AD Ledbetter… - Toxicology and applied …, 2000 - Elsevier
Cardiovascular disease is considered a probable risk factor of particulate matter (PM)-
related mortality and morbidity. It was hypothesized that rats with hereditary systemic …
related mortality and morbidity. It was hypothesized that rats with hereditary systemic …
Acute pulmonary toxicity of particulate matter filter extracts in rats: coherence with epidemiologic studies in Utah Valley residents.
JA Dye, JR Lehmann, JK McGee… - Environmental …, 2001 - ehp.niehs.nih.gov
Epidemiologic reports by CA Pope III et. al. demonstrated that in the Utah Valley, closure of
an open-hearth steel mill over the winter of 1987 was associated with reductions in …
an open-hearth steel mill over the winter of 1987 was associated with reductions in …
Oxidant generation and lung injury after particulate air pollutant exposure increase with the concentrations of associated metals
RJ Pritchard, AJ Ghio, JR Lehmann… - Inhalation …, 1996 - Taylor & Francis
We tested the hypothesis that particulate air pollutants are associated with metals that have
a capacity to transport electrons and that biologic activity of the particulates can correlate …
a capacity to transport electrons and that biologic activity of the particulates can correlate …
TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmias in hypertensive rats exposed to diesel exhaust
MS Hazari, N Haykal-Coates, DW Winsett… - Environmental …, 2011 - ehp.niehs.nih.gov
Background: Diesel exhaust (DE), which is emitted from on-and off-road sources, is a
complex mixture of toxic gaseous and particulate components that leads to triggered …
complex mixture of toxic gaseous and particulate components that leads to triggered …
Metal and sulfate composition of residual oil fly ash determines airway hyperreactivity and lung injury in rats
SH Gavett, SL Madison, KL Dreher, DW Winsett… - Environmental …, 1997 - Elsevier
The biological effects of particulate matter (PM) deposition in the airways may depend on
aqueous-leachable chemical constituents of the particles. The effects of two residual oil fly …
aqueous-leachable chemical constituents of the particles. The effects of two residual oil fly …
ST depression, arrhythmia, vagal dominance, and reduced cardiac micro-RNA in particulate-exposed rats
AK Farraj, MS Hazari, N Haykal-Coates… - American journal of …, 2011 - atsjournals.org
Recently, investigators demonstrated associations between fine particulate matter (PM)–
associated metals and adverse health effects. Residual oil fly ash (ROFA), a waste product …
associated metals and adverse health effects. Residual oil fly ash (ROFA), a waste product …
Whole and particle-free diesel exhausts differentially affect cardiac electrophysiology, blood pressure, and autonomic balance in heart failure–prone rats
AP Carll, MS Hazari, CM Perez, QT Krantz… - Toxicological …, 2012 - academic.oup.com
Epidemiological studies strongly link short-term exposures to vehicular traffic and particulate
matter (PM) air pollution with adverse cardiovascular (CV) events, especially in those with …
matter (PM) air pollution with adverse cardiovascular (CV) events, especially in those with …
Overt and latent cardiac effects of ozone inhalation in rats: evidence for autonomic modulation and increased myocardial vulnerability
AK Farraj, MS Hazari, DW Winsett… - Environmental …, 2012 - ehp.niehs.nih.gov
Background: Ozone (O3) is a well-documented respiratory oxidant, but increasing
epidemiological evidence points to extrapulmonary effects, including positive associations …
epidemiological evidence points to extrapulmonary effects, including positive associations …
Acrolein inhalation alters arterial blood gases and triggers carotid body-mediated cardiovascular responses in hypertensive rats
CM Perez, MS Hazari, AD Ledbetter… - Inhalation …, 2015 - Taylor & Francis
Context: Air pollution exposure affects autonomic function, heart rate, blood pressure and left
ventricular function. While the mechanism for these effects is uncertain, several studies have …
ventricular function. While the mechanism for these effects is uncertain, several studies have …
Continuous electrocardiogram reveals differences in the short-term cardiotoxic response of Wistar-Kyoto and spontaneously hypertensive rats to doxorubicin
MS Hazari, N Haykal-Coates, DW Winsett… - Toxicological …, 2009 - academic.oup.com
Electrocardiography (ECG) is one of the standard technologies used to monitor and assess
cardiac function, and provide insight into the mechanisms driving myocardial pathology …
cardiac function, and provide insight into the mechanisms driving myocardial pathology …