Could MRI be used to image kidney fibrosis? A review of recent advances and remaining barriers
A key contributor to the progression of nearly all forms of CKD is fibrosis, a largely
irreversible process that drives further kidney injury. Despite its importance, clinicians …
irreversible process that drives further kidney injury. Despite its importance, clinicians …
YAP/TAZ are mechanoregulators of TGF-β-Smad signaling and renal fibrogenesis
SG Szeto, M Narimatsu, M Lu, X He… - Journal of the …, 2016 - journals.lww.com
Like many organs, the kidney stiffens after injury, a process that is increasingly recognized
as an important driver of fibrogenesis. Yes-associated protein (YAP) and transcriptional …
as an important driver of fibrogenesis. Yes-associated protein (YAP) and transcriptional …
The (Pro)Renin Receptor: Site-Specific and Functional Linkage to the Vacuolar H+-ATPase in the Kidney
The (pro) renin receptor ([P] RR) is a transmembrane protein that binds both renin and
prorenin with high affinity, increasing the catalytic cleavage of angiotensinogen and …
prorenin with high affinity, increasing the catalytic cleavage of angiotensinogen and …
[HTML][HTML] Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide …
A Advani, Q Huang, K Thai, SL Advani, KE White… - The American journal of …, 2011 - Elsevier
Epigenetic changes in gene expression play a role in the development of diabetic
complications, including nephropathy. Histone deacetylases (HDACs) are a group of …
complications, including nephropathy. Histone deacetylases (HDACs) are a group of …
eNOS deficiency predisposes podocytes to injury in diabetes
DA Yuen, BE Stead, Y Zhang, KE White… - Journal of the …, 2012 - journals.lww.com
Endothelial nitric oxide synthase (eNOS) deficiency may contribute to the pathogenesis of
diabetic nephropathy in both experimental models and humans, but the underlying …
diabetic nephropathy in both experimental models and humans, but the underlying …
NUAK1 promotes organ fibrosis via YAP and TGF-β/SMAD signaling
T Zhang, X He, L Caldwell, SK Goru… - Science Translational …, 2022 - science.org
Fibrosis is a central pathway that drives progression of multiple chronic diseases, yet few
safe and effective clinical antifibrotic therapies exist. In most fibrotic disorders, transforming …
safe and effective clinical antifibrotic therapies exist. In most fibrotic disorders, transforming …
[HTML][HTML] Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor
RE Gilbert, Q Huang, K Thai, SL Advani, K Lee… - Kidney international, 2011 - Elsevier
Clinical trials and experimental studies have highlighted the importance of epigenetic
processes in the development of diabetic complications. One of the earliest features of …
processes in the development of diabetic complications. One of the earliest features of …
[HTML][HTML] Myofibroblast YAP/TAZ activation is a key step in organ fibrogenesis
X He, MF Tolosa, T Zhang, SK Goru, LU Severino… - JCI insight, 2022 - ncbi.nlm.nih.gov
Fibrotic diseases account for nearly half of all deaths in the developed world. Despite its
importance, the pathogenesis of fibrosis remains poorly understood. Recently, the two …
importance, the pathogenesis of fibrosis remains poorly understood. Recently, the two …
[HTML][HTML] International Society of Nephrology first consensus guidance for preclinical animal studies in translational nephrology
Preclinical tests in animal models are key steps in early drug development. Consequently,
the International Society of Nephrology held a consensus meeting that connected experts in …
the International Society of Nephrology held a consensus meeting that connected experts in …
Magnetic resonance elastography to assess fibrosis in kidney allografts
A Kirpalani, E Hashim, G Leung, JK Kim… - Clinical Journal of the …, 2017 - journals.lww.com
Results Sixteen patients who underwent magnetic resonance elastography and biopsy were
studied (mean age: 54±9 years old). Whole-kidney mean stiffness ranged between 3.5 and …
studied (mean age: 54±9 years old). Whole-kidney mean stiffness ranged between 3.5 and …