A key contributor to the progression of nearly all forms of CKD is fibrosis, a largely
irreversible process that drives further kidney injury. Despite its importance, clinicians …

Like many organs, the kidney stiffens after injury, a process that is increasingly recognized
as an important driver of fibrogenesis. Yes-associated protein (YAP) and transcriptional …

The (pro) renin receptor ([P] RR) is a transmembrane protein that binds both renin and
prorenin with high affinity, increasing the catalytic cleavage of angiotensinogen and …

Epigenetic changes in gene expression play a role in the development of diabetic
complications, including nephropathy. Histone deacetylases (HDACs) are a group of …

Endothelial nitric oxide synthase (eNOS) deficiency may contribute to the pathogenesis of
diabetic nephropathy in both experimental models and humans, but the underlying …

Fibrosis is a central pathway that drives progression of multiple chronic diseases, yet few
safe and effective clinical antifibrotic therapies exist. In most fibrotic disorders, transforming …

Clinical trials and experimental studies have highlighted the importance of epigenetic
processes in the development of diabetic complications. One of the earliest features of …

Fibrotic diseases account for nearly half of all deaths in the developed world. Despite its
importance, the pathogenesis of fibrosis remains poorly understood. Recently, the two …

Preclinical tests in animal models are key steps in early drug development. Consequently,
the International Society of Nephrology held a consensus meeting that connected experts in …

Results Sixteen patients who underwent magnetic resonance elastography and biopsy were
studied (mean age: 54±9 years old). Whole-kidney mean stiffness ranged between 3.5 and …