The control of diastolic calcium in the heart: basic mechanisms and functional implications

DA Eisner, JL Caldwell, AW Trafford… - Circulation …, 2020 - Am Heart Assoc
Normal cardiac function requires that intracellular Ca2+ concentration be reduced to low
levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often …

Recent advances in phase matching of second‐order nonlinearities in monolithic semiconductor waveguides

AS Helmy, P Abolghasem… - Laser & Photonics …, 2011 - Wiley Online Library
Techniques used to assist phase matching of second‐order nonlinearities in semiconductor
waveguides are reviewed. The salient points of each method are highlighted, with their …

Phosphodiesterase type-5 inhibitor use in type 2 diabetes is associated with a reduction in all-cause mortality

SG Anderson, DC Hutchings, M Woodward, K Rahimi… - Heart, 2016 - heart.bmj.com
Objective Experimental evidence has shown potential cardioprotective actions of
phosphodiesterase type-5 inhibitors (PDE5is). We investigated whether PDE5i use in …

[HTML][HTML] Monolithically-integrated TE-mode 1D silicon-on-insulator isolators using seedlayer-free garnet

C Zhang, P Dulal, BJH Stadler, DC Hutchings - Scientific reports, 2017 - nature.com
The first experimental TE-mode silicon-on-insulator (SOI) isolators using Faraday Rotation
are here realized to fill the 'missing link'in source-integrated near infrared photonic circuits …

Optimized magneto-optical isolator designs inspired by seedlayer-free terbium iron garnets with opposite chirality

P Dulal, AD Block, TE Gage, HA Haldren… - ACS …, 2016 - ACS Publications
Simulations demonstrate that undoped yttrium iron garnet (YIG) seedlayers cause reduced
Faraday rotation in silicon-on-insulator waveguides with Ce-doped YIG claddings. Undoped …

[HTML][HTML] Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responses

W Wu, W Zhang, JL Booth, DC Hutchings, X Wang… - Respiratory …, 2016 - Springer
Background Cigarette smoking (CS) is the main risk factor for the development of chronic
obstructive pulmonary disease (COPD) and most COPD exacerbations are caused by …

[HTML][HTML] Phosphodiesterase 5 inhibition improves contractile function and restores transverse tubule loss and catecholamine responsiveness in heart failure

M Lawless, JL Caldwell, EJ Radcliffe, CER Smith… - Scientific reports, 2019 - nature.com
Heart failure (HF) is characterized by poor survival, a loss of catecholamine reserve and
cellular structural remodeling in the form of disorganization and loss of the transverse tubule …

Interaction of background Ca2+ influx, sarcoplasmic reticulum threshold and heart failure in determining propensity for Ca2+ waves in sheep heart

DC Hutchings, GWP Madders, BC Niort… - The Journal of …, 2022 - Wiley Online Library
Ventricular arrhythmias can cause death in heart failure (HF). A trigger is the occurrence of
Ca2+ waves which activate a Na+‐Ca2+ exchange (NCX) current, leading to delayed after …

A waveguide polarization toolset design based on mode beating

DC Hutchings, BM Holmes - IEEE Photonics Journal, 2011 - ieeexplore.ieee.org
A toolset of waveguide elements is examined, which can be combined to produce
polarization functional devices in a single contiguous waveguide. In particular, waveguide …

PDE5 Inhibition Suppresses Ventricular Arrhythmias by Reducing SR Ca2+ Content

DC Hutchings, CM Pearman, GWP Madders… - Circulation …, 2021 - Am Heart Assoc
Rationale: PDE5 (phosphodiesterase 5) inhibition reduces the occurrence of ventricular
arrhythmias following myocardial ischemia. However, the mechanisms of the antiarrhythmic …