User profiles for "author:David Lefroy"

David Lefroy

Consultant Cardiologist, Hammersmith Hospital, London
Verified email at nhs.net
Cited by 4539

Development and validation of a new adenosine-independent index of stenosis severity from coronary wave–intensity analysis: results of the ADVISE (ADenosine …

S Sen, J Escaned, IS Malik, GW Mikhail… - Journal of the American …, 2012 - jacc.org
Objectives: The purpose of this study was to develop an adenosine-independent, pressure-
derived index of coronary stenosis severity. Background: Assessment of stenosis severity …

[HTML][HTML] Reduced coronary vasodilator function in infarcted and normal myocardium after myocardial infarction

NG Uren, T Crake, DC Lefroy, R de Silva… - … England Journal of …, 1994 - Mass Medical Soc
Background The ability of the coronary vascular bed to dilate and thus increase blood flow to
the myocardium may be impaired in coronary artery disease, even in regions of myocardium …

Pulmonary venous isolation by antral ablation with a large cryoballoon for treatment of paroxysmal and persistent atrial fibrillation: medium-term outcomes and non …

P Kojodjojo, MD O'Neill, PB Lim, L Malcolm-Lawes… - Heart, 2010 - heart.bmj.com
Background To prevent atrial fibrillation (AF) recurrence after catheter ablation, pulmonary
venous isolation (PVI) at an antral level is more effective than segmental ostial ablation …

His resynchronization versus biventricular pacing in patients with heart failure and left bundle branch block

AD Arnold, MJ Shun-Shin, D Keene, JP Howard… - Journal of the American …, 2018 - jacc.org
Background: His bundle pacing is a new method for delivering cardiac resynchronization
therapy (CRT). Objectives: The authors performed a head-to-head, high-precision, acute …

Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans.

DC Lefroy, T Crake, NG Uren, GJ Davies, A Maseri - Circulation, 1993 - Am Heart Assoc
BACKGROUND NG-Monomethyl-L-arginine (L-NMMA), a specific inhibitor of nitric oxide
synthesis, was used to determine the effects of inhibition of nitric oxide synthesis in the …

[HTML][HTML] Classification performance of instantaneous wave-free ratio (iFR) and fractional flow reserve in a clinical population of intermediate coronary stenoses: results …

R Petraco, J Escaned, S Sen, S Nijjer… - …, 2013 - eurointervention.pcronline.com
Aims: To evaluate the classification agreement between instantaneous wave-free ratio (iFR)
and fractional flow reserve (FFR) in patients with angiographic intermediate coronary …

[HTML][HTML] Delayed recovery of coronary resistive vessel function after coronary angioplasty

NG Uren, T Crake, DC Lefroy, R De Silva… - Journal of the American …, 1993 - Elsevier
Objectives. The aim of this study was to use Doppler catheterization and sequential dynamic
positron emission tomography (PET) to investigate the role and time course of abnormal …

Hybrid iFR-FFR decision-making strategy: implications for enhancing universal adoption of physiology-guided coronary revascularization

R Petraco, JJ Park, S Sen, S Nijjer, I Malik… - American Journal of …, 2013 - ajconline.org
Background Adoption of fractional flow reserve (FFR) remains low (6-8%), partly because of
the time, cost and potential inconvenience associated with vasodilator administration. The …

17-beta-Estradiol therapy lessens angina in postmenopausal women with syndrome X

GMC Ross, NS Peters, D Lefroy, DC Lindsay… - Journal of the American …, 1996 - Elsevier
Objectives. We sought to investigate the hypothesis that estrogen replacement therapy
ameliorates symptoms in postmenopausal women with syndrome X. Background. Syndrome …

Comparison of methods for delivering cardiac resynchronization therapy: an acute electrical and haemodynamic within-patient comparison of left bundle branch area …

N Ali, AD Arnold, AA Miyazawa, D Keene, JJ Chow… - Europace, 2023 - academic.oup.com
Aims Left bundle branch area pacing (LBBAP) is a promising method for delivering cardiac
resynchronization therapy (CRT), but its relative physiological effectiveness compared with …