The Parkinson Progression Marker Initiative (PPMI) is a comprehensive observational,
international, multi-center study designed to identify PD progression biomarkers both to …

▪ Abstract The synthesis and excretion of bile acids comprise the major pathway of
cholesterol catabolism in mammals. Synthesis provides a direct means of converting …

Lipids are produced, transported, and recognized by the concerted actions of numerous
enzymes, binding proteins, and receptors. A comprehensive analysis of lipid molecules," …

The expression of protective immunity to Mycobacterium tuberculosis in mice is mediated by
T lymphocytes that secrete cytokines. These molecules then mediate a variety of roles …

2 GOLDSTEIN ET AL depended on the sequential cell surface binding, internalization, and
intracellular degradation of plasma low density lipoprotein (LDL)(Goldstein & Brown 1974 …

Previous studies demonstrated that antidepressant treatment increases the expression of
brain-derived neurotrophic factor (BDNF) in rat hippocampus. The present study was …

The focus of the present study was to define the human plasma lipidome and to establish
novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid …

The human cytochrome P450 (CYP) superfamily comprises 57 genes. These genes code for
enzymes that can have a role in: metabolism of drugs, foreign chemicals, arachidonic acid …

Here we describe the cloning and characterization of a PAS domain transcription factor
termed endothelial PAS-1 (EPAS1). This protein shares 48% sequence identity with hypoxia …

A central paradigm of immunology is clonal selection: lymphocytes displaying clonally
distributed antigen receptors are generated and subsequently selected by antigen for …