Purpose—Our goal is to provide an overview of the current evidence about components of
the evaluation and treatment of adults with acute ischemic stroke. The intended audience is …

Aim This clinical practice guideline for the evaluation and diagnosis of chest pain provides
recommendations and algorithms for clinicians to assess and diagnose chest pain in adult …

Background The magnitude of effect of sodium-glucose cotransporter-2 inhibitors (SGLT2i)
on specific cardiovascular and renal outcomes and whether heterogeneity is based on key …

Background The cardiovascular safety profile of dapagliflozin, a selective inhibitor of sodium–
glucose cotransporter 2 that promotes glucosuria in patients with type 2 diabetes, is …

Background The cardiovascular safety and efficacy of many current antihyperglycemic
agents, including saxagliptin, a dipeptidyl peptidase 4 (DPP-4) inhibitor, are unclear …

Background Dual antiplatelet therapy with clopidogrel plus low-dose aspirin has not been
studied in a broad population of patients at high risk for atherothrombotic events. Methods …

Background Increases in lipid levels and cancers with tofacitinib prompted a trial of major
adverse cardiovascular events (MACE) and cancers in patients with rheumatoid arthritis …

Background Prior unblinded studies have suggested that catheter-based renal-artery
denervation reduces blood pressure in patients with resistant hypertension. Methods We …

Background We evaluated whether rivaroxaban alone or in combination with aspirin would
be more effective than aspirin alone for secondary cardiovascular prevention. Methods In …

Background Patients with elevated triglyceride levels are at increased risk for ischemic
events. Icosapent ethyl, a highly purified eicosapentaenoic acid ethyl ester, lowers …