User profiles for "author:Denise Hilfiker-Kleiner"

Denise Hilfiker-Kleiner

Professor of molecular cardiology and cardiovascular side effects in oncologic therapies
Verified email at uni-marburg.de
Cited by 29508

Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association …

K Sliwa, D Hilfiker-Kleiner, MC Petrie… - European journal of …, 2010 - Wiley Online Library
Peripartum cardiomyopathy (PPCM) is a cause of pregnancy-associated heart failure. It
typically develops during the last month of, and up to 6 months after, pregnancy in women …

Sex differences in heart failure

CSP Lam, C Arnott, AL Beale… - European heart …, 2019 - academic.oup.com
The overall lifetime risk of heart failure (HF) is similar between men and women, however,
there are marked sex differences in the landscape of this condition that are both important …

Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology

T Eschenhagen, T Force, MS Ewer… - European journal of …, 2011 - Wiley Online Library
The reductions in mortality and morbidity being achieved among cancer patients with current
therapies represent a major achievement. However, given their mechanisms of action, many …

[HTML][HTML] A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy

D Hilfiker-Kleiner, K Kaminski, E Podewski, T Bonda… - Cell, 2007 - cell.com
Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women
to high risk of mortality after delivery. Here, we show that female mice with a cardiomyocyte …

Expression of angiotensin II and interleukin 6 in human coronary atherosclerotic plaques: potential implications for inflammation and plaque instability

B Schieffer, E Schieffer, D Hilfiker-Kleiner, A Hilfiker… - Circulation, 2000 - Am Heart Assoc
Background—Patients with an activated renin-angiotensin system (RAS) or genetic
alterations of the RAS are at increased risk of myocardial infarction (MI). Administration of …

Evaluation of bromocriptine in the treatment of acute severe peripartum cardiomyopathy: a proof-of-concept pilot study

K Sliwa, L Blauwet, K Tibazarwa, E Libhaber… - Circulation, 2010 - Am Heart Assoc
Background—Peripartum cardiomyopathy (PPCM) is a potentially life-threatening heart
disease that occurs in previously healthy women. We identified prolactin, mainly its 16-kDa …

Cardiac angiogenic imbalance leads to peripartum cardiomyopathy

IS Patten, S Rana, S Shahul, GC Rowe, C Jang, L Liu… - Nature, 2012 - nature.com
Peripartum cardiomyopathy (PPCM) is an often fatal disease that affects pregnant women
who are near delivery, and it occurs more frequently in women with pre-eclampsia and/or …

Statin-induced improvement of endothelial progenitor cell mobilization, myocardial neovascularization, left ventricular function, and survival after experimental …

U Landmesser, N Engberding, FH Bahlmann… - Circulation, 2004 - Am Heart Assoc
Background—Endothelial nitric oxide (eNO) bioavailability is severely reduced after
myocardial infarction (MI) and in heart failure. Statins enhance eNO availability by both …

[HTML][HTML] MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy

J Halkein, SP Tabruyn, M Ricke-Hoch… - The Journal of …, 2013 - Am Soc Clin Investig
Peripartum cardiomyopathy (PPCM) is a life-threatening pregnancy-associated
cardiomyopathy in previously healthy women. Although PPCM is driven in part by the 16 …

[HTML][HTML] mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in …

A Hilfiker, D Hilfiker‐Kleiner, A Pannuti… - The EMBO …, 1997 - embopress.org
Dosage compensation is a regulatory process that insures that males and females have
equal amounts of X‐chromosome gene products. In Drosophila, this is achieved by a 2‐fold …