Sex, ageing and resting blood pressure: gaining insights from the integrated balance of neural and haemodynamic factors

EC Hart, MJ Joyner, BG Wallin… - The Journal of …, 2012 - Wiley Online Library
Young women tend to have lower blood pressure, and less risk of hypertension, compared
to young men. As people age, both blood pressure and the risk of hypertension increase in …

Recording sympathetic nerve activity in conscious humans and other mammals: guidelines and the road to standardization

EC Hart, GA Head, JR Carter… - American Journal …, 2017 - journals.physiology.org
Over the past several decades, studies of the sympathetic nervous system in humans,
sheep, rabbits, rats, and mice have substantially increased mechanistic understanding of …

[HTML][HTML] Neural control of the circulation: how sex and age differences interact in humans

MJ Joyner, JN Barnes, EC Hart, BG Wallin… - Comprehensive …, 2015 - ncbi.nlm.nih.gov
The autonomic nervous system is a key regulator of cardiovascular system. In this review we
focus on how sex and aging influence autonomic regulation of blood pressure in humans in …

Sex differences in sympathetic neural-hemodynamic balance: implications for human blood pressure regulation

EC Hart, N Charkoudian, BG Wallin, TB Curry… - …, 2009 - Am Heart Assoc
Among young normotensive men, a reciprocal balance between cardiac output and
sympathetic nerve activity is important in the regulation of arterial pressure. In young women …

Sex and ageing differences in resting arterial pressure regulation: the role of the β‐adrenergic receptors

EC Hart, N Charkoudian, BG Wallin… - The Journal of …, 2011 - Wiley Online Library
Non‐Technical Summary In young men, sympathetic nerve activity is directly related to the
level of vasoconstrictor tone in the peripheral vasculature. However, in young women this …

Unilateral carotid body resection in resistant hypertension: a safety and feasibility trial

K Narkiewicz, LEK Ratcliffe, EC Hart, LJB Briant… - JACC: Basic to …, 2016 - jacc.org
Animal and human data indicate pathological afferent signaling emanating from the carotid
body that drives sympathetically mediated elevations in blood pressure in conditions of …

Purinergic receptors in the carotid body as a new drug target for controlling hypertension

W Pijacka, DJA Moraes, LEK Ratcliffe… - Nature medicine, 2016 - nature.com
In view of the high proportion of individuals with resistance to antihypertensive medication
and/or poor compliance or tolerance of this medication, new drugs to treat hypertension are …

Influence of age and sex on the pressor response following a spontaneous burst of muscle sympathetic nerve activity

LC Vianna, EC Hart, ST Fairfax… - American Journal …, 2012 - journals.physiology.org
The sympathetic nervous system is critical for the beat-to-beat regulation of arterial blood
pressure (BP). Although studies have examined age-and sex-related effects on BP control …

Investigation and treatment of high blood pressure in young people: too much medicine or appropriate risk reduction?

TC Hinton, ZH Adams, RP Baker, KA Hope… - …, 2020 - Am Heart Assoc
Hypertension among young people is common, affecting 1 in 8 adults aged between 20 and
40 years. This number is likely to increase with lifestyle behaviors and lowering of …

Aging enhances autonomic support of blood pressure in women

JN Barnes, EC Hart, TB Curry, WT Nicholson… - …, 2014 - Am Heart Assoc
The autonomic nervous system plays a central role in both acute and chronic blood pressure
regulation in humans. The activity of the sympathetic branch of the autonomic nervous …