Genetic Markers of Toxicity From Capecitabine and Other Fluorouracil-Based Regimens:
Investigation in the QUASAR2 Study, Systematic Review, and Meta-Analysis - PMC Back to Top …

Many individuals with multiple or large colorectal adenomas or early-onset colorectal cancer
(CRC) have no detectable germline mutations in the known cancer predisposition genes …

Cancer chromosomal instability (CIN) results in an increased rate of change of chromosome
number and structure and generates intratumour heterogeneity,. CIN is observed in most …

To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide
association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal …

To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide
association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal …

Genome-wide association (GWA) studies have identified multiple loci at which common
variants modestly influence the risk of developing colorectal cancer (CRC). To enhance …

Genome-wide association studies (GWAS) have identified ten loci harboring common
variants that influence risk of developing colorectal cancer (CRC). To enhance the power to …

Background Improved markers of prognosis are needed to stratify patients with early-stage
colorectal cancer to refine selection of adjuvant therapy. The aim of the present study was to …

Accurate duplication of DNA prior to cell division is essential to suppress mutagenesis and
tumour development. The high fidelity of eukaryotic DNA replication is due to a combination …

We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with
colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 …