First described over 80 years ago, ataxia-telangiectasia (AT) was defined as a clinical entity
50 years ago. Although not encountered by most clinicians, it is a paradigm for cancer …

▪ Abstract The autosomal recessive human disorder ataxia-telangiectasia (AT) was first
described as a separate disease entity 40 years ago. It is a multisystem disease …

The genome of the malaria parasite, Plasmodium falciparum, contains a myosin gene
sequence, which bears a close homology to one of the myosin genes found in another …

A number of proteins are activated by stress stimuli but none so spectacularly or with the
degree of complexity as the tumour suppressor p53 (human p53 gene or protein). Once …

It is accepted that formative assessment can lead to gains in attainment. Although claims
have also been made that these techniques bring benefits in terms of self-esteem and …

A gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia (AT)
was identified by positional cloning on chromosome 11q22-23. AT is characterized by …

Plasmodium falciparum merozoites have an array of 2–3 subpellicular microtubules,
designated f-MAST. We have previously shown that colchicine inhibits merozoite invasion of …

The ataxia-telangiectasia mutated (ATM) protein kinase is activated by DNA double-strand
breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and …

Background The absence of trial data comparing robot-assisted laparoscopic prostatectomy
and open radical retropubic prostatectomy is a crucial knowledge gap in uro-oncology. We …

The human genetic disorder ataxia-telangiectasia (AT) is characterized by
immunodeficiency, progressive cerebellar ataxia, radiosensitivity, cell cycle checkpoint …