Mechanoresponsive networks controlling vascular inflammation
MT Bryan, H Duckles, S Feng, ST Hsiao… - … , and vascular biology, 2014 - Am Heart Assoc
Atherosclerosis is a chronic inflammatory disease of arteries that develops preferentially at
branches and bends that are exposed to disturbed blood flow. Vascular function is modified …
branches and bends that are exposed to disturbed blood flow. Vascular function is modified …
Disturbed flow promotes endothelial senescence via a p53-dependent pathway
CM Warboys, A de Luca, N Amini, L Luong… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Although atherosclerosis is associated with systemic risk factors such as age,
high cholesterol, and obesity, plaque formation occurs predominately at branches and …
high cholesterol, and obesity, plaque formation occurs predominately at branches and …
Experimental approaches to study endothelial responses to shear stress
N Bowden, MT Bryan, H Duckles, S Feng… - Antioxidants & Redox …, 2016 - liebertpub.com
Significance: Shear stress controls multiple physiological processes in endothelial cells
(ECs). Recent Advances: The response of ECs to shear has been studied using a range of …
(ECs). Recent Advances: The response of ECs to shear has been studied using a range of …
[HTML][HTML] Heme oxygenase-1 regulates cell proliferation via carbon monoxide-mediated inhibition of T-type Ca2+ channels
H Duckles, HE Boycott, MM Al-Owais, J Elies… - … -European Journal of …, 2015 - Springer
Induction of the antioxidant enzyme heme oxygenase-1 (HO-1) affords cellular protection
and suppresses proliferation of vascular smooth muscle cells (VSMCs) associated with a …
and suppresses proliferation of vascular smooth muscle cells (VSMCs) associated with a …
Heart rate reduction with ivabradine promotes shear stress-dependent anti-inflammatory mechanisms in arteries
L Le, H Duckles, T Schenkel… - Thrombosis and …, 2016 - thieme-connect.com
Blood flow generates wall shear stress (WSS) which alters endothelial cell (EC) function.
Low WSS promotes vascular inflammation and atherosclerosis whereas high uniform WSS …
Low WSS promotes vascular inflammation and atherosclerosis whereas high uniform WSS …
T-Type Ca2+ Channel Regulation by CO: A Mechanism for Control of Cell Proliferation
H Duckles, MM Al-Owais, J Elies, E Johnson… - … in Physiology and …, 2015 - Springer
T-type Ca 2+ channels regulate proliferation in a number of tissue types, including vascular
smooth muscle and various cancers. In such tissues, up-regulation of the inducible enzyme …
smooth muscle and various cancers. In such tissues, up-regulation of the inducible enzyme …
[BOOK][B] The vascular smooth muscle T-type Ca2+ channel: An anti-proliferative target for heme oxygenase-1
H Duckles - 2013 - etheses.whiterose.ac.uk
Pathological proliferation of vascular smooth muscle cells (VSMC) is a central feature of
vascular disorders such as atherosclerosis and restenosis. During such proliferative …
vascular disorders such as atherosclerosis and restenosis. During such proliferative …
Disturbed flow influences endothelial activation by inducing homeobox transcription factors
I Gauci, M Mahmoud, H Duckles, S Feng… - …, 2014 - atherosclerosis-journal.com
Results: Varicose saphenous veins removed during phlebectomy and normal saphenous
veins obtained during coronary artery bypass surgeries were collected for proteomics …
veins obtained during coronary artery bypass surgeries were collected for proteomics …
192 The Induction of Homeobox Genes by Disturbed Flow Limits Inflammation at Atherosusceptible Sites
I Gauci, L Luong, M Mahmoud, H Duckles, S Hsiao… - Heart, 2014 - heart.bmj.com
Introduction Atherosclerosis develops at branches and bends of arteries exposed to
disturbed blood flow, whereas regions exposed to uniform flow are protected. Disturbed flow …
disturbed blood flow, whereas regions exposed to uniform flow are protected. Disturbed flow …
A Pharmacological Approach to Promote Shear Stress-Dependent Anti-inflammatory Mechanisms in Arteries
L Luong, H Duckles, T Schenkel, N Arnold… - … and Vascular Biology, 2014 - Am Heart Assoc
Atherosclerosis is influenced by blood flow whichS exert wall shear stress (WSS) on
endothelial cells (EC). Low oscillatory WSS promotes atherosclerosis by inducing …
endothelial cells (EC). Low oscillatory WSS promotes atherosclerosis by inducing …