Background In studies of all-cause mortality, the fundamental epidemiological concepts of
rate and risk are connected through a well-defined one-to-one relation. An important …

Bootstrap methods have gained wide acceptance and huge popularity in the field of applied
statistics. The bootstrap is able to provide accurate answers in cases where other methods …

Background The role of adjuvant chemotherapy for patients with rectal cancer after
preoperative (chemo) radiotherapy and surgery is uncertain. We did a meta-analysis of …

Background Short-term preoperative radiotherapy and total mesorectal excision have each
been shown to improve local control of disease in patients with resectable rectal cancer. We …

Extensive epidemiologic studies have suggested that adult disease risk is associated with
adverse environmental conditions early in development. Although the mechanisms behind …

Standard survival data measure the time span from some time origin until the occurrence of
one type of event. If several types of events occur, a model describing progression to each of …

Background Historical data and recent studies show that standardised extended (D2)
lymphadenectomy leads to better results than standardised limited (D1) lymphadenectomy …

Background The TME trial investigated the value of preoperative short-term radiotherapy in
combination with total mesorectal excision (TME). Long-term results are reported after a …

Objective: To investigate the efficacy of preoperative short-term radiotherapy in patients with
mobile rectal cancer undergoing total mesorectal excision (TME) surgery. Summary …

Background After surgery for intermediate-risk endometrial carcinoma, the vagina is the
most frequent site of recurrence. This study established whether vaginal brachytherapy …