[HTML][HTML] The broad spectrum of LMNA cardiac diseases: from molecular mechanisms to clinical phenotype
S Crasto, I My, E Di Pasquale - Frontiers in Physiology, 2020 - frontiersin.org
Mutations of Lamin A/C gene (LMNA) cause laminopathies, a group of disorders associated
with a wide spectrum of clinically distinct phenotypes, affecting different tissues and organs …
with a wide spectrum of clinically distinct phenotypes, affecting different tissues and organs …
Common cardiovascular risk factors and in-hospital mortality in 3,894 patients with COVID-19: survival analysis and machine learning-based findings from the …
Background and aims There is poor knowledge on characteristics, comorbidities and
laboratory measures associated with risk for adverse outcomes and in-hospital mortality in …
laboratory measures associated with risk for adverse outcomes and in-hospital mortality in …
[HTML][HTML] Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19
Abstract Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity,
involved in resistance to selected pathogens and in the regulation of inflammation,–. The …
involved in resistance to selected pathogens and in the regulation of inflammation,–. The …
Use of hydroxychloroquine in hospitalised COVID-19 patients is associated with reduced mortality: Findings from the observational multicentre Italian CORIST study
Background Hydroxychloroquine (HCQ) was proposed as potential treatment for COVID-19.
Objective We set-up a multicenter Italian collaboration to investigate the relationship …
Objective We set-up a multicenter Italian collaboration to investigate the relationship …
Early detection of elevated cardiac biomarkers to optimise risk stratification in patients with COVID-19
Objective Risk stratification is crucial to optimise treatment strategies in patients with COVID-
19. We aimed to evaluate the impact on mortality of an early assessment of cardiac …
19. We aimed to evaluate the impact on mortality of an early assessment of cardiac …
The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association …
Background Respiratory failure is a key feature of severe Covid-19 and a critical driver of
mortality, but for reasons poorly defined affects less than 10% of SARS-CoV-2 infected …
mortality, but for reasons poorly defined affects less than 10% of SARS-CoV-2 infected …
Detailed stratified GWAS analysis for severe COVID-19 in four European populations
F Degenhardt, D Ellinghaus, S Juzenas… - Human molecular …, 2022 - academic.oup.com
Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a
deeper analysis of the host genetic contribution to severe COVID-19 is important to improve …
deeper analysis of the host genetic contribution to severe COVID-19 is important to improve …
[HTML][HTML] Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors
CM Poch, KS Foo, MT De Angelis, K Jennbacken… - Nature cell …, 2022 - nature.com
Heart regeneration is an unmet clinical need, hampered by limited renewal of adult
cardiomyocytes and fibrotic scarring. Pluripotent stem cell-based strategies are emerging …
cardiomyocytes and fibrotic scarring. Pluripotent stem cell-based strategies are emerging …
BNT162b2 vaccine induces antibody release in saliva: a possible role for mucosal viral protection?
Vaccination against an airborne pathogen is very effective if it induces also the development
of mucosal antibodies that can protect against infection. The mRNA‐based vaccine …
of mucosal antibodies that can protect against infection. The mRNA‐based vaccine …
[HTML][HTML] Pulsed-field ablation-based pulmonary vein isolation: acute safety, efficacy and short-term follow-up in a multi-center real world scenario
MD Lemoine, T Fink, C Mencke, R Schleberger… - Clinical Research in …, 2023 - Springer
Purpose Pulsed-field ablation (PFA) is a new energy source to achieve pulmonary vein
isolation (PVI) by targeted electroporation of cardiomyocytes. Experimental and controlled …
isolation (PVI) by targeted electroporation of cardiomyocytes. Experimental and controlled …