Pentameric ligand-gated ion channels (pLGICs) mediate fast synaptic communication by
converting chemical signals into an electrical response. Recently solved agonist-bound and …

MEASURING THE BURDEN OF SECONDARY INSULTS IN HEAD INJURED PATIENTS
DURING INTENSIVE CARE Patricia A. Jones, Peter JD Andrews, ^Susan Midgley, Shirley I …

Revised Manuscript Received May 4, 1994® abstract: A probe has been developed that can
rapidly measure micromolar concentrations of inorganic phosphate (P¡), in particular to …

The structural change that generates force and motion in actomyosin motility has been
proposed to be tilting of the myosin light chain domain, which serves as a lever arm. Several …

G-protein–coupled receptors (GPCRs) are the largest family of transmembrane signaling
proteins in the human genome. Events in the GPCR signaling cascade have been well …

The first adult case of 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) deficiency is
described. The impaired conversion of cortisol to cortisone (indicated by urinary cortisol and …

In 70 paired insulin tolerance tests (ITTs) and short'Synacthen'tests (SSTs), both of which
have been advocated for assessment of the hypothalamo-pituitary-adrenal (HPA) axis, there …

Reagents capable of rapid and efficient release of neuroactive amino acids (l-glutamate,
GABA and glycine) upon flash photolysis of thermally stable, inert precursors have been …

The mechanism of Pi interaction with phosphate binding protein of Escherichia coli has
been investigated using the A197C mutant protein labeled with a coumarin fluorophore …

A new method is described for measuring motions of protein domains in their native
environment on the physiological timescale. Pairs of cysteines are introduced into the …