strongly with insulin resistance. Excess upper body fat can accumulate either
intraperitoneally (visceral fat) or subcutaneously. Many investigators claim that excess …

Abstract...... 531 Preface...... 532 Introduction...... 533 Methods...... 533 Indication
Development...... 533 Scope of Indications...... 533 Panel Selection...... 534 Rating Process …

Discussion...... 1410 References...... 1414 Appendix A...... 1416 Appendix B...... 1419
Appendix C...... 1432 Appendix D...... 1433 Preamble Medicine is experiencing an …

Background In patients with stable coronary artery disease, it remains unclear whether an
initial management strategy of percutaneous coronary intervention (PCI) with intensive …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes …

(ACCF) guidelines on secondary prevention, 1 important evidence from clinical trials has
emerged that further supports and broadens the merits of intensive risk-reduction therapies …

The recommendations listed in this document are, whenever possible, evidence based. An
extensive evidence review was conducted as the document was compiled through …

We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …

Background Among patients with stable coronary disease and moderate or severe ischemia,
whether clinical outcomes are better in those who receive an invasive intervention plus …

Background—Extent and severity of myocardial ischemia are determinants of risk for
patients with coronary artery disease, and ischemia reduction is an important therapeutic …