User profiles for "author:J. D. Allen"

Joel D. Allen

- Verified email at soton.ac.uk - Cited by 4836

Jason David Allen

- Verified email at virginia.edu - Cited by 4650

James D Allen

- Verified email at strose.edu - Cited by 1292

Lung Master Protocol (Lung-MAP)—a biomarker-driven protocol for accelerating development of therapies for squamous cell lung cancer: SWOG S1400

RS Herbst, DR Gandara, FR Hirsch, MW Redman… - Clinical cancer …, 2015 - AACR
Abstract The Lung Master Protocol (Lung-MAP, S1400) is a groundbreaking clinical trial
designed to advance the efficient development of targeted therapies for squamous cell …

Tumor mutational burden standardization initiatives: recommendations for consistent tumor mutational burden assessment in clinical samples to guide immunotherapy …

A Stenzinger, JD Allen, J Maas… - Genes …, 2019 - Wiley Online Library
Abstract Characterization of tumors utilizing next‐generation sequencing methods, including
assessment of the number of somatic mutations (tumor mutational burden [TMB]), is currently …

Multidrug resistance and pharmacological protection mediated by the breast cancer resistance protein (BCRP/ABCG2)

JD Allen, AH Schinkel - Molecular cancer therapeutics, 2002 - AACR
Over the past 15 years it has become clear that drug exporters of the ABC3 family (1) can
both confer MDR to cancer cells and mediate extensive protection of intact organisms …

Site-specific glycan analysis of the SARS-CoV-2 spike

Y Watanabe, JD Allen, D Wrapp, JS McLellan… - Science, 2020 - science.org
The emergence of the betacoronavirus, severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), represents a …

Potent and Specific Inhibition of the Breast Cancer Resistance Protein Multidrug Transporter in Vitro and in Mouse Intestine by a Novel Analogue of Fumitremorgin C

JD Allen, A Van Loevezijn, JM Lakhai… - Molecular cancer …, 2002 - AACR
Inhibitors of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter are of
interest as chemosensitizers for clinical drug resistance, for improving the pharmacokinetics …

[PDF][PDF] Human neutralizing antibodies against SARS-CoV-2 require intact Fc effector functions for optimal therapeutic protection

ES Winkler, P Gilchuk, J Yu, AL Bailey, RE Chen… - Cell, 2021 - cell.com
SARS-CoV-2 has caused the global COVID-19 pandemic. Although passively delivered
neutralizing antibodies against SARS-CoV-2 show promise in clinical trials, their mechanism …

The Mouse Bcrp1/Mxr/Abcp Gene: Amplification and Overexpression in Cell Lines Selected for Resistance to Topotecan, Mitoxantrone, or Doxorubicin

JD Allen, RF Brinkhuis, J Wijnholds, AH Schinkel - Cancer research, 1999 - AACR
Mouse fibroblast cell lines lacking functional Mdr1a, Mdr1b, and Mrp1 genes were selected
for resistance to topotecan, mitoxantrone, or doxorubicin. Each of the resulting drug-resistant …

Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease

AA Kenjale, KL Ham, T Stabler… - Journal of applied …, 2011 - journals.physiology.org
Peripheral arterial disease (PAD) results in a failure to adequately supply blood and oxygen
(O2) to working tissues and presents as claudication pain during walking. Nitric oxide (NO) …

Impact of dietary nitrate supplementation via beetroot juice on exercising muscle vascular control in rats

SK Ferguson, DM Hirai, SW Copp… - The Journal of …, 2013 - Wiley Online Library
Key points• Inorganic nitrate (NO3−) supplementation with beetroot juice (BR) in humans
lowers blood pressure and the O2 cost of exercise and may improve exercise tolerance …

Testing hadronic interactions at ultrahigh energies with air showers measured by the Pierre Auger Observatory

A Aab, P Abreu, M Aglietta, EJ Ahn, I Al Samarai… - Physical review …, 2016 - APS
Ultrahigh energy cosmic ray air showers probe particle physics at energies beyond the
reach of accelerators. Here we introduce a new method to test hadronic interaction models …