Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?

JS Yudkin, M Kumari, SE Humphries, V Mohamed-Ali - Atherosclerosis, 2000 - Elsevier
There is mounting evidence that inflammation plays a role in the development of coronary
heart disease (CHD). Observations have been made linking the presence of infections in the …

Diabetes in sub-Saharan Africa: from clinical care to health policy

R Atun, JI Davies, EAM Gale… - The lancet Diabetes & …, 2017 - thelancet.com
Executive summary Rapid demographic, sociocultural, and economic transitions are driving
increases in the risk and prevalence of diabetes and other non-communicable diseases …

Diabetes care in sub-Saharan Africa

D Beran, JS Yudkin - The Lancet, 2006 - thelancet.com
The increasing numbers of people with type 2 diabetes is a worldwide concern. It presents
an added challenge in sub-Saharan Africa, where diabetes must compete for resources with …

C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose …

JS Yudkin, CDA Stehouwer, JJ Emeis… - … , and vascular biology, 1999 - Am Heart Assoc
C-reactive protein, a hepatic acute phase protein largely regulated by circulating levels of
interleukin-6, predicts coronary heart disease incidence in healthy subjects. We have shown …

Subcutaneous Adipose Tissue Releases Interleukin-6, But Not Tumor Necrosis Factor-α, in Vivo

V Mohamed-Ali, S Goodrick, A Rawesh… - The Journal of …, 1997 - academic.oup.com
We measured arterio-venous differences in concentrations of tumor necrosis factor-α (TNFα)
and interleukin-6 (IL-6) across a sc adipose tissue bed in the postabsorptive state in 39 …

The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic …

D Fishman, G Faulds, R Jeffery… - The Journal of …, 1998 - Am Soc Clin Investig
During active disease, patients with systemic-onset juvenile chronic arthritis (S-JCA)
demonstrate a rise and fall in serum interleukin-6 (IL-6) that parallels the classic quotidian …

Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes (UKPDS 36): prospective observational study

AI Adler, IM Stratton, HAW Neil, JS Yudkin… - Bmj, 2000 - bmj.com
Objective: To determine the relation between systolic blood pressure over time and the risk
of macrovascular or microvascular complications in patients with type 2 diabetes. Design …

Frequency of the WHO metabolic syndrome in European cohorts, and an alternative definition of an insulin resistance syndrome.

B Balkau, MA Charles, T Drivsholm… - Diabetes & …, 2002 - europepmc.org
Background To describe the frequency, in some European populations, of the World Health
Organisation (WHO) defined metabolic syndrome and to compare the frequency of this …

Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study

SA Stanner, K Bulmer, C Andres, OE Lantseva… - Bmj, 1997 - bmj.com
Objective: To investigate the relation between decreased maternal food intake and risk
factors for coronary heart disease in adult Design: Cross sectional study. Subjects: 169 …

Endothelial dysfunction: cause of the insulin resistance syndrome

JH Pinkney, CDA Stehouwer, SW Coppack… - Diabetes, 1997 - Am Diabetes Assoc
Insulin resistance has been proposed as the metabolic basis of atherogenesis. This
hypothesis is based on the concept of the “insulin resistance syndrome,” according to which …