This Review is intended to help clinicians, patients, and the public make informed decisions
about statin therapy for the prevention of heart attacks and strokes. It explains how the …

Atherosclerosis is a leading cause of vascular disease worldwide. Its major clinical
manifestations include ischemic heart disease, ischemic stroke, and peripheral arterial …

Statins are effective cholesterol-lowering drugs that reduce the risk of cardiovascular
disease events (heart attacks, strokes, and the need for arterial revascularisation). Adverse …

Background Lowering LDL cholesterol with statin regimens reduces the risk of myocardial
infarction, ischaemic stroke, and the need for coronary revascularisation in people without …

Importance Current guidelines advocate the use of marine-derived omega-3 fatty acids
supplements for the prevention of coronary heart disease and major vascular events in …

Genome-wide association studies have identified 11 common variants convincingly
associated with coronary artery disease (CAD),,,,,,, a modest number considering the …

Background Statin therapy has been shown to reduce major vascular events and vascular
mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety …

Elevated plasma homocysteine levels have been associated with higher risks of
cardiovascular disease, but the effects on disease rates of supplementation with folic acid to …

Background Lowering of LDL cholesterol reduces major vascular events, but whether more
intensive therapy safely produces extra benefi ts is uncertain. We aimed to establish effi cacy …

Background Statin therapy is effective for the prevention of atherosclerotic cardiovascular
disease and is widely prescribed, but there are persisting concerns that statin therapy might …