Objective To characterise the determinants, time course, and risks of acute myocardial
infarction associated with use of oral non-steroidal anti-inflammatory drugs (NSAIDs) …

Background: The recent increase in the number and severity of cases of nosocomial
Clostridium difficile-associated diarrhea (CDAD) has prompted interest in the use of …

Background Multiple randomized controlled trials (RCTs) have examined the cardiovascular
effects of omega-3 fatty acids and have provided unexplained conflicting results. A meta …

Background Drug-eluting stents (DES) are associated with lower restenosis rates than bare-
metal stents (BMS), but the benefits and safety of the new devices have not been …

Objectives: The purpose of this study was to determine if statins (hydroxymethylglutaryl CoA
reductase inhibitors [HMG-CoA]), angiotensin-converting enzyme (ACE) inhibitors, and …

Purpose: Congestive heart failure is an important cause of patient morbidity and mortality.
Although several randomized clinical trials have compared β-blockers with placebo for …

Conventional nonsteroidal antiinflammatory drugs (NSAIDs) are associated with acute renal
failure, but cyclooxygenase-2 inhibitors have not been comparatively evaluated. The authors …

Background: Anticoagulants and antiplatelet drugs (eg, warfarin, clopidogrel and
acetylsalicylic acid) are key therapeutic agents in the treatment of cardiovascular diseases …

Background: Coronary stents are widely used in interventional cardiology, but a current
quantitative systematic overview comparing routine coronary stenting with standard …

Context Fluoroquinolones are commonly prescribed classes of antibiotics. Despite
numerous case reports of ocular toxicity, a pharmacoepidemiological study of their ocular …