Concomitant use of clopidogrel and proton pump inhibitors: impact on platelet function and clinical outcome-a systematic review

JJ Focks, MA Brouwer, MGH van Oijen, A Lanas… - Heart, 2013 - heart.bmj.com
Background Clopidogrel as an adjunct to aspirin has improved outcomes after acute
coronary syndromes, but laboratory studies suggest a reduced antiplatelet effect when …

Polypharmacy and effects of apixaban versus warfarin in patients with atrial fibrillation: post hoc analysis of the ARISTOTLE trial

JJ Focks, MA Brouwer, DM Wojdyla, L Thomas… - Bmj, 2016 - bmj.com
Objective To determine whether the treatment effect of apixaban versus warfarin differs with
increasing numbers of concomitant drugs used by patients with atrial fibrillation. Design Post …

[HTML][HTML] Gastrointestinal symptoms are still prevalent and negatively impact health-related quality of life: a large cross-sectional population based study in The …

MM Tielemans, J Jaspers Focks, LGM van Rossum… - PLoS …, 2013 - journals.plos.org
Background Over the last decades important risk factors for gastrointestinal symptoms have
shifted, which may have changed its population prevalence. The aim of this study was to …

Assessment of plasma aminothiol levels and the association with recurrent atherothrombotic events in patients hospitalized for an acute coronary syndrome: a …

JJ Focks, A van Schaik, N Clappers… - Clinical Chemistry and …, 2013 - degruyter.com
Background: The aminothiols homocysteine and, to a lesser extent, cysteine have been
associated with adverse cardiovascular outcome, whereas glutathione, as an antioxidant …

High platelet reactivity–the challenge of prolonged anticoagulation therapy after ACSI

MA Brouwer, JJ Focks… - Thrombosis and …, 2013 - thieme-connect.com
Despite dual antiplatelet therapy (DAPT), one-year event rates after acute coronary
syndrome (ACS) vary from 9–12%. The development of novel oral anticoagulants (NOAC) …

Novel antithrombotic challenges: head, heart, and guts

MA Brouwer, JJ Focks, FWA Verheugt - Gastroenterology, 2013 - gastrojournal.org
Dear Sir: We read with interest the article on the increased risk of gastrointestinal bleeding
(GIB), associated with the use of the novel oral anticoagulants (NOAC). 1 We compliment the …

Rivaroxaban Plasma Levels and Levetiracetam

MA Brouwer, SPG van Vugt, JJ Focks… - Annals of Internal …, 2020 - acpjournals.org
TO THE EDITOR: We read Paciullo and colleagues' case report (1) with interest. Especially
during the coronavirus disease 2019 (COVID-19) pandemic, this information is crucial for …

TCT-576 Serum Cholesterol Levels Do Not Influence Lipid Core Burden Index

F Mensink, J Los, M Reda, JJ Focks… - Journal of the American …, 2022 - jacc.org
Background High lipid content in the coronary artery vessel wall is predictive of future major
adverse cardiac events. The lipid core burden index (LCBI) as measured by near-infrared …

The effect of implementation of resuscitation guidelines 2005 on short and long term survival in patients with ventricular fibrillation

WT Bots, W Keuper, J Jaspers Focks, JL Bonnes… - 2010 - Am Heart Assoc
Purpose: In 2005 guidelines for resuscitation were altered to improve survival. However, in
studies comparing the former 2000 and current 2005 guidelines conflicting results have …

Comparison of incident dyspepsia between low-dose plain aspirin and enteric-coated aspirin

MGH van Oijen, JJ Focks, RJF Laheij - Clinical Gastroenterology and …, 2010 - cghjournal.org
Dear Editor: With interest we read the special report by Arora et al regarding the use of
proton pump inhibitors for gastroduodenal damage related to nonsteroidal anti-inflammatory …