INTRODUCTION More than 50% of patients treated with chimeric antigen receptor (CAR)–T
cells for B cell malignancies develop progressive disease after CAR therapy, and these …

Natural sequence variation within mitochondrial DNA (mtDNA) contributes to human
phenotypes and may serve as natural genetic markers in human cells for clonal and lineage …

Fibromyalgia syndrome (FMS) is characterized by widespread pain and tenderness, and
patients typically experience fatigue and emotional distress. The etiology and …

Capsaicin-sensitive, TRPV1 (transient receptor potential vanilloid 1) receptor-expressing
primary sensory neurons exert local and systemic efferent effects besides the classical …

Objective An interesting and so far unexplained feature of chronic pain in autoimmune
disease is the frequent disconnect between pain and inflammation. This is illustrated well in …

Chronic antigen exposure during viral infection or cancer promotes an exhausted T cell
(Tex) state with reduced effector function. However, whether all antigen-specific T cell clones …

T cells are the major arm of the immune system responsible for controlling and regressing
cancers. To identify genes limiting T cell function, we conducted genome-wide CRISPR …

Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors (PAC1, VPAC)
are present in sensory neurons and vascular smooth muscle. PACAP infusion was found to …

The transient receptor potential vanilloid 1 (TRPV1) receptor is a nonselective cation
channel localized on a subset of primary sensory neurons and can be activated by a wide …

Although elevated levels of anti-citrullinated protein antibodies (ACPAs) are a hallmark of
rheumatoid arthritis (RA), the in vivo functions of these antibodies remain unclear. Here, we …