Cardiovascular pathologies are still the primary cause of death worldwide. The molecular
mechanisms behind these pathologies have not been fully elucidated. Unravelling them will …

Stent deployment following balloon angioplasty is used routinely to treat coronary artery
disease. These interventions cause damage and loss of endothelial cells (EC), and thus …

In this review, the role of wall shear stress in the chicken embryonic heart is analyzed to
determine its effect on cardiac development through regulating gene expression. Therefore …

Objective—Proinflammatory mediators influence atherosclerosis by inducing adhesion
molecules (eg, VCAM-1) on endothelial cells (ECs) via signaling intermediaries including …

Primary cilia are mechanosensors for fluid shear stress, and are involved in a number of
syndromes and congenital anomalies. We identified endothelial cilia in areas of low shear …

Expert recommendations on the assessment of wall shear stress in human coronary arteries:
existing methodologies, technical considerations, and clinical applications | European Heart …

Atherosclerosis develops in the arterial system at sites of low as well as low and oscillating
shear stress. Previously, we demonstrated a shear-related distribution of ciliated endothelial …

Rationale: Blood flow–induced shear stress controls endothelial cell (EC) physiology during
atherosclerosis via transcriptional mechanisms that are incompletely understood. The …

Blood flow influences atherosclerosis by generating wall shear stress, which alters
endothelial cell (EC) physiology. Low shear stress induces dedifferentiation of EC through a …

During cardiovascular development, fluid shear stress patterns change dramatically due to
extensive remodeling. This biomechanical force has been shown to drive gene expression …