Background—Lymphedema after surgery, infection, or radiation therapy is a common and
often incurable problem. Application of lymphangiogenic growth factors has been shown to …

Objective: Our objective was to define the optimal growth factor treatment to be used in
combination with lymph node transfer to normalize lymphatic vascular anatomy …

Abstract Introduction VEGF-C156S, a lymphangiogenesis-specific form of vascular
endothelial growth factor C (VEGF-C), has been considered as a promising candidate for the …

Background Cardiovascular patients suffer from reduced blood flow leading to ischaemia
and impaired tissue metabolism. Unfortunately, an increasing group of elderly patients …

Objective Coronary heart disease remains a significant clinical problem, and new therapies
are needed especially for patients with refractory angina for whom the current therapies do …

A large animal model of chronic myocardial ischemia and heart failure is crucial for the
development of novel therapeutic approaches. In this study we developed a novel …

Background: Cardiovascular diseases are the leading cause of death globally. In spite of the
availability of improved treatments, there is still a large group of chronic ischemia patients …

Despite multiple previous studies in the field of vascular anomalies, the mechanism (s)
leading to their development, progression and maintenance has remained unclear. In this …

Background Short proximal neck of an abdominal aortic aneurysm is associated with risk of
treatment failure during abdominal aortic repair. Important side branches, such as renal …

In this thesis, stimulation of the growth of both lymphatic and blood vessels was studied in
large animal models using adenovirally (Ad) delivered vascular endothelial growth factors …