Sodium–glucose cotransporter-2 inhibitors versus glucagon-like peptide-1 receptor agonists and the risk for cardiovascular outcomes in routine care patients with …
E Patorno, PT Htoo, RJ Glynn… - Annals of internal …, 2021 - acpjournals.org
Background: Both sodium–glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like
peptide-1 receptor agonists (GLP-1 RAs) have shown cardiovascular benefits in placebo …
peptide-1 receptor agonists (GLP-1 RAs) have shown cardiovascular benefits in placebo …
[HTML][HTML] Hydroxychloroquine lowers Alzheimer's disease and related dementias risk and rescues molecular phenotypes related to Alzheimer's disease
We recently nominated cytokine signaling through the Janus-kinase–signal transducer and
activator of transcription (JAK/STAT) pathway as a potential AD drug target. As …
activator of transcription (JAK/STAT) pathway as a potential AD drug target. As …
Association of type of oral anticoagulant dispensed with adverse clinical outcomes in patients extending anticoagulation therapy beyond 90 days after hospitalization …
Importance Guidelines for managing venous thromboembolism (VTE) recommend at least
90 days of therapy with oral anticoagulants. Limited evidence exists about the optimal drug …
90 days of therapy with oral anticoagulants. Limited evidence exists about the optimal drug …
Incidence of venous thromboembolism in patients with dermatologist-diagnosed chronic inflammatory skin diseases
Importance Several studies have linked chronic inflammatory skin diseases (CISDs) with
venous thromboembolism (VTE) in a range of data sources with mixed conclusions …
venous thromboembolism (VTE) in a range of data sources with mixed conclusions …
Epidemiologic characterization of heart failure with reduced or preserved ejection fraction populations identified using Medicare claims
Background Administrative claims do not contain ejection fraction information for heart
failure patients. We recently developed and validated a claims-based model to predict …
failure patients. We recently developed and validated a claims-based model to predict …
Comparative risk of Alzheimer disease and related dementia among Medicare beneficiaries with rheumatoid arthritis treated with targeted disease-modifying …
Importance Cytokine signaling, including tumor necrosis factor (TNF) and interleukin (IL)-6,
through the Janus-kinase (JAK)–signal transducer and activator of transcription pathway …
through the Janus-kinase (JAK)–signal transducer and activator of transcription pathway …
Effectiveness of angiotensin-neprilysin inhibitor treatment versus renin-angiotensin system blockade in older adults with heart failure in clinical care
Objective To evaluate the effectiveness of angiotensin receptor-neprilysin inhibitor (ARNI)
versus renin-angiotensin system (RAS) blockade alone in older adults with heart failure with …
versus renin-angiotensin system (RAS) blockade alone in older adults with heart failure with …
Targeting abnormal metabolism in Alzheimer's disease: The Drug Repurposing for Effective Alzheimer's Medicines (DREAM) study
Drug discovery for disease‐modifying therapies for Alzheimer's disease and related
dementias (ADRD) based on the traditional paradigm of experimental animal models has …
dementias (ADRD) based on the traditional paradigm of experimental animal models has …
[HTML][HTML] External validation of a claims-based model to predict left ventricular ejection fraction class in patients with heart failure
Background Ejection fraction (EF) is an important prognostic factor in heart failure (HF), but
administrative claims databases lack information on EF. We previously developed a model …
administrative claims databases lack information on EF. We previously developed a model …
A multi-modal approach to evaluate the impact of risk evaluation and mitigation strategy (REMS) programs
Abstract Introduction Since 2007, the US Food and Drug Administration has had the
authority to require risk evaluation and mitigation strategy (REMS) programs for certain …
authority to require risk evaluation and mitigation strategy (REMS) programs for certain …