Continuous time representation approach to batch and continuous process scheduling. 1. MINLP formulation

L Mockus, GV Reklaitis - Industrial & Engineering Chemistry …, 1999 - ACS Publications
The problem of decision timing in the context of batch and continuous process scheduling is
addressed in this paper. Representation of time in any scheduling model affects the number …

Bayesian approach to global optimization and application to multiobjective and constrained problems

JB Mockus, LJ Mockus - Journal of optimization theory and applications, 1991 - Springer
In this paper, the Bayesian methods of global optimization are considered. They provide the
minimal expected deviation from the global minimum. It is shown that, using the Bayesian …

Simulation-optimization approach to clinical trial supply chain management with demand scenario forecast

Y Chen, L Mockus, S Orcun, GV Reklaitis - Computers & Chemical …, 2012 - Elsevier
In the pharmaceutical industry, the development activities that are required to bring a new
drug to market involve considerable expense (upwards of $1 Billion) and can take in excess …

[PDF][PDF] The impact of mobile access on motivation: Distance education student perceptions

L Mockus, H Dawson, S Edel-Malizia… - World Campus …, 2011 - learningdesign.psu.edu
In the last few years, the telecommunications field has experienced an exponential growth in
network coverage, speed, and technological innovation in the United States and around the …

A framework for schedule evaluation with processing uncertainty

SJ Honkomp, L Mockus, GV Reklaitis - Computers & chemical engineering, 1999 - Elsevier
The scheduling of batch chemical processes has been the focus of a substantial amount of
research, focused primarily on building schedules for processes which are assumed to …

Batch-to-batch variation: a key component for modeling chemical manufacturing processes

L Mockus, JJ Peterson, JM Lainez… - … Process Research & …, 2015 - ACS Publications
For chemical manufacturing processes, the chemical kinetics literature contains virtually no
mention of quantitative models that involve batch-to-batch variation. Models for chemical …

Quality by design in formulation and process development for a freeze-dried, small molecule parenteral product: a case study

LN Mockus, TW Paul, NA Pease… - Pharmaceutical …, 2011 - Taylor & Francis
A case study has been developed to illustrate one way of incorporating a Quality by Design
approach into formulation and process development for a small molecule, freeze-dried …

Mathematical programming formulation for scheduling of batch operations based on nonuniform time discretization

L Mockus, GV Reklaitis - Computers & chemical engineering, 1997 - Elsevier
A flexible formulation for handling a wide range of short-term scheduling problems arising in
multi-product/multipurpose batch chemical plants is presented. Time is directly used to …

Morphology of ambulatory ST segment changes in patients with varying severity of coronary artery disease. Investigation of the frequency of nocturnal ischaemia and …

AA Quyyumi, L Mockus, C Wright, KM Fox - Heart, 1985 - heart.bmj.com
The frequency and magnitude of objectively determined myocardial ischaemia during
normal daily activities of patients with varying severity of coronary artery disease are …

Factors influencing efficacy of an area-wide pest management program in three urban forests

CS Sadof, L Mockus, MD Ginzel - Urban forestry & urban greening, 2021 - Elsevier
Managing exotic invasive pests like emerald ash borer can strain budgets and the capacity
of cities to protect their urban forest. Area-wide management approaches, like SLAM (SL. ow …