User profiles for "author:Leonard Buckbinder"
Leonard BuckbinderVice President, Biology; Scorpion Therapeutics Verified email at scorpiontx.com Cited by 5339 |
Myeloperoxidase inhibition improves ventricular function and remodeling after experimental myocardial infarction
PF-1355 is an oral myeloperoxidase (MPO) inhibitor that successfully decreased elevated
MPO activity in mouse myocardial infarction models. Short duration PF-1355 treatment for 7 …
MPO activity in mouse myocardial infarction models. Short duration PF-1355 treatment for 7 …
Induction of the growth inhibitor IGF-binding protein 3 by p53
L Buckbinder, R Talbott, S Velasco-Miguel, I Takenaka… - Nature, 1995 - nature.com
TRANSCRIPTIONAL activation of target genes represents an important component of the
tumour-suppressor function of p53 and provides a functional link between p53 and various …
tumour-suppressor function of p53 and provides a functional link between p53 and various …
NF-κB RelA phosphorylation regulates RelA acetylation
The nuclear functions of NF-κB p50/RelA heterodimers are regulated in part by
posttranslational modifications of its RelA subunit, including phosphorylation and …
posttranslational modifications of its RelA subunit, including phosphorylation and …
[HTML][HTML] Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …
of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide …
PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes
S Velasco-Miguel, L Buckbinder, P Jean, L Gelbert… - Oncogene, 1999 - nature.com
Exposure of mammalian cells to hypoxia, radiation and certain chemotherapeutic agents
promotes cell cycle arrest and/or apoptosis. Activation of p53 responsive genes is believed …
promotes cell cycle arrest and/or apoptosis. Activation of p53 responsive genes is believed …
Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis
L Buckbinder, DT Crawford, H Qi… - Proceedings of the …, 2007 - National Acad Sciences
Bone is accrued and maintained primarily through the coupled actions of bone-forming
osteoblasts and bone-resorbing osteoclasts. Cumulative in vitro studies indicated that …
osteoblasts and bone-resorbing osteoclasts. Cumulative in vitro studies indicated that …
Identification of novel pheno-groups in heart failure with preserved ejection fraction using machine learning
Objective Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous
syndrome. We aimed to derive HFpEF phenotype-based groups ('phenogroups') based on …
syndrome. We aimed to derive HFpEF phenotype-based groups ('phenogroups') based on …
[HTML][HTML] Structural characterization of proline-rich tyrosine kinase 2 (PYK2) reveals a unique (DFG-out) conformation and enables inhibitor design
S Han, A Mistry, JS Chang, D Cunningham… - Journal of biological …, 2009 - ASBMB
Proline-rich tyrosine kinase 2 (PYK2) is a cytoplasmic, non-receptor tyrosine kinase
implicated in multiple signaling pathways. It is a negative regulator of osteogenesis and …
implicated in multiple signaling pathways. It is a negative regulator of osteogenesis and …
The glucocorticoid receptor: molecular mechanism and new therapeutic opportunities
L Buckbinder, RP Robinson - Current Drug Targets …, 2002 - ingentaconnect.com
Synthetic glucocorticoids are among the most effective anti-inflammatory drugs available.
The activity of this drug class is mediated by the glucocorticoid receptor, a nuclear steroid …
The activity of this drug class is mediated by the glucocorticoid receptor, a nuclear steroid …
[HTML][HTML] Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis
RJ Roth Flach, A Skoura, A Matevossian… - Nature …, 2015 - nature.com
Signalling pathways that control endothelial cell (EC) permeability, leukocyte adhesion and
inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate …
inflammation are pivotal for atherosclerosis initiation and progression. Here we demonstrate …