Controversies in ventricular remodelling

LH Opie, PJ Commerford, BJ Gersh, MA Pfeffer - The Lancet, 2006 - thelancet.com
Ventricular remodelling describes structural changes in the left ventricle in response to
chronic alterations in loading conditions, with three major patterns: concentric remodelling …

Beta‐blockers for hypertension

CS Wiysonge, HA Bradley, J Volmink… - Cochrane database …, 2017 - cochranelibrary.com
Background Beta‐blockers refer to a mixed group of drugs with diverse pharmacodynamic
and pharmacokinetic properties. They have shown long‐term beneficial effects on mortality …

Cardiovascular remodelling in coronary artery disease and heart failure

G Heusch, P Libby, B Gersh, D Yellon, M Böhm… - The Lancet, 2014 - thelancet.com
Remodelling is a response of the myocardium and vasculature to a range of potentially
noxious haemodynamic, metabolic, and inflammatory stimuli. Remodelling is initially …

2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European …

Task Force Members, G Montalescot… - European heart …, 2013 - academic.oup.com
Surveys and registries are needed to verify that real-life daily practice is in keeping with what
is recommended in the guidelines, thus completing the loop between clinical research …

[BOOK][B] Heart physiology: from cell to circulation

LH Opie - 2004 - books.google.com
Thoroughly revised and updated, this Fourth Edition is the only current book that integrates
cellular and subcellular elements of cardiovascular physiology in the analysis of physiologic …

Metabolic mechanisms in heart failure

H Ashrafian, MP Frenneaux, LH Opie - Circulation, 2007 - Am Heart Assoc
Although neurohumoral antagonism has successfully reduced heart failure morbidity and
mortality, the residual disability and death rate remains unacceptably high. Though …

Hypertension in sub-Saharan African populations

LH Opie, YK Seedat - Circulation, 2005 - Am Heart Assoc
Background—Hypertension in sub-Saharan Africa is a widespread problem of immense
economic importance because of its high prevalence in urban areas, its frequent …

The red wine hypothesis: from concepts to protective signalling molecules

LH Opie, S Lecour - European heart journal, 2007 - academic.oup.com
We review evidence for and against the 'red wine hypothesis', whereby red wine is more
likely to confer cardiovascular benefits than white. As background, there is a strong …

[BOOK][B] Drugs for the heart E-book

LH Opie, BJ Gersh - 2011 - books.google.com
The new edition of this market-leading cardiac drug resource equips you with the latest
advances in cardiovascular pharmacology, one of the most rapidly changing areas of …

Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway

L Lacerda, S Somers, LH Opie… - Cardiovascular …, 2009 - academic.oup.com
Abstract Aims Ischaemic postconditioning (IPostC) is a powerful protective phenomenon that
activates prosurvival intrinsic signalling cascades to limit reperfusion injury. We propose that …