[HTML][HTML] The diagnosis and management of von Willebrand disease: a United Kingdom Haemophilia Centre Doctors Organization guideline approved by the British …

MA Laffan, W Lester, JS O'Donnell, A Will… - British journal of …, 2014 - ncbi.nlm.nih.gov
Von Willebrand factor (VWF) is a large and complex plasma glycoprotein that is essential for
normal haemostasis. It is well recognized that deficiency of VWF results in a bleeding …

[HTML][HTML] COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects

DM Smadja, SJ Mentzer, M Fontenay, MA Laffan… - Angiogenesis, 2021 - Springer
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is presenting as a systemic disease associated with …

Randomised trials of human albumin for adults with sepsis: systematic review and meta-analysis with trial sequential analysis of all-cause mortality

A Patel, MA Laffan, U Waheed, SJ Brett - Bmj, 2014 - bmj.com
Objective To assess the efficacy and safety of pooled human albumin solutions as part of
fluid volume expansion and resuscitation (with or without improvement of baseline …

Whole-genome sequencing of patients with rare diseases in a national health system

E Turro, WJ Astle, K Megy, S Gräf, D Greene… - Nature, 2020 - nature.com
Most patients with rare diseases do not receive a molecular diagnosis and the aetiological
variants and causative genes for more than half such disorders remain to be discovered …

Endothelial von Willebrand factor regulates angiogenesis

RD Starke, F Ferraro, KE Paschalaki… - Blood, The Journal …, 2011 - ashpublications.org
The regulation of blood vessel formation is of fundamental importance to many physiological
processes, and angiogenesis is a major area for novel therapeutic approaches to diseases …

[BOOK][B] Dacie and Lewis Practical Haematology E-Book: Dacie and Lewis Practical Haematology E-Book

BJ Bain, I Bates, MA Laffan - 2016 - books.google.com
For more than 65 years, this best-selling text by Drs. Barbara J. Bain, Imelda Bates, and Mike
A. Laffan has been the worldwide standard in laboratory haematology. The 12th Edition of …

The relationship between ABO histo‐blood group, factor VIII and von Willebrand factor

J O'donnell, MA Laffan - Transfusion Medicine, 2001 - Wiley Online Library
. ABO histo‐blood group is a major determinant of plasma levels of factor VIII (FVIII) and von
Willebrand factor (vWF). Blood group O individuals have significantly (approximately 25%) …

[BOOK][B] Dacie and Lewis practical haematology: expert consult: online and print

BJ Bain, I Bates, MA Laffan, SM Lewis - 2016 - books.google.com
Highly Commended at 2012 BMA awards in Internal Medicine Category. Recognized
worldwide as the standard reference work, Dacie & Lewis Practical Haematology is a must …

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders

I Simeoni, JC Stephens, F Hu… - Blood, The Journal …, 2016 - ashpublications.org
Inherited bleeding, thrombotic, and platelet disorders (BPDs) are diseases that affect∼ 300
individuals per million births. With the exception of hemophilia and von Willebrand disease …

[HTML][HTML] Von Willebrand factor and angiogenesis: basic and applied issues

AM Randi, MA Laffan - Journal of Thrombosis and Haemostasis, 2017 - Elsevier
The recent discovery that von Willebrand factor (VWF) regulates blood vessel formation has
opened a novel perspective on the function of this complex protein. VWF was discovered as …