A systematic review of genetic polymorphisms and breast cancer risk
AM Dunning, CS Healey, PDP Pharoah… - … Biomarkers & Prevention, 1999 - AACR
Studies investigating the relationship between common genetic variants and cancer risk are
being reported with rapidly increasing frequency. We have identified 46 published case …
being reported with rapidly increasing frequency. We have identified 46 published case …
Genetic linkage studies
MD Teare, JH Barrett - The Lancet, 2005 - thelancet.com
Linkage analysis is used to map genetic loci by use of observations of related individuals.
We provide an introduction to methods commonly used to map loci that predispose to …
We provide an introduction to methods commonly used to map loci that predispose to …
[PDF][PDF] Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families
The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage
and mutation analysis in 237 families, each with at least four cases of breast cancer …
and mutation analysis in 237 families, each with at least four cases of breast cancer …
Risk prediction models for lung cancer: a systematic review
EP Gray, MD Teare, J Stevens, R Archer - Clinical lung cancer, 2016 - Elsevier
Many lung cancer risk prediction models have been published but there has been no
systematic review or comprehensive assessment of these models to assess how they could …
systematic review or comprehensive assessment of these models to assess how they could …
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
Although several lung cancer susceptibility loci have been identified, much of the heritability
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …
for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European …
[HTML][HTML] Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study
MD Teare, M Dimairo, N Shephard, A Hayman… - Trials, 2014 - Springer
Background External pilot or feasibility studies can be used to estimate key unknown
parameters to inform the design of the definitive randomised controlled trial (RCT). However …
parameters to inform the design of the definitive randomised controlled trial (RCT). However …
A genetic register for von Hippel-Lindau disease.
IR Maddock, A Moran, ER Maher, MD Teare… - Journal of medical …, 1996 - jmg.bmj.com
A genetic register for von Hippel-Lindau disease was set up in the north west of England in
1990. Population statistics, clinical features, age at onset, and survival of 83 people affected …
1990. Population statistics, clinical features, age at onset, and survival of 83 people affected …
[PDF][PDF] Mutations in the gene encoding capillary morphogenesis protein 2 cause juvenile hyaline fibromatosis and infantile systemic hyalinosis
S Hanks, S Adams, J Douglas, L Arbour… - The American Journal of …, 2003 - cell.com
Juvenile hyaline fibromatosis (JHF) and infantile systemic hyalinosis (ISH) are autosomal
recessive conditions characterized by multiple subcutaneous skin nodules, gingival …
recessive conditions characterized by multiple subcutaneous skin nodules, gingival …
[HTML][HTML] Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium
BACKGROUND AND METHODS: Familial aggregation of lung cancer exists after
accounting for cigarette smoking. However, the extent to which family history affects risk by …
accounting for cigarette smoking. However, the extent to which family history affects risk by …
Optimizing the yield and utility of circulating cell-free DNA from plasma and serum
X Xue, MD Teare, I Holen, YM Zhu, PJ Woll - Clinica chimica acta, 2009 - Elsevier
BACKGROUND: Cell-free DNA (CFDNA) in the plasma/serum of patients with cancer
demonstrates tumour-associated genetic alterations, offering possibilities for diagnosis …
demonstrates tumour-associated genetic alterations, offering possibilities for diagnosis …